Triocim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triocim 400 mg capsule | ৳ 60.00 | ৳ 360.00 |
Description
Overview of the medicine
Triocim (Cefixime) 400 mg capsule is a broad-spectrum cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily, or 200 mg every 12 hours. For uncomplicated gonorrhea, a single dose of 400 mg is recommended.
Elderly
No specific dose adjustment is required solely based on age. However, dose should be adjusted based on renal function if impaired.
Renal_impairment
For creatinine clearance 21-60 mL/min, the dose should be reduced to 300 mg daily. For creatinine clearance <20 mL/min, the dose should be 200 mg daily.
How to Take
Triocim capsules should be taken orally with water. It can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell wall disruption and bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after oral administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. The rest is eliminated via non-renal mechanisms, likely biliary.
Half life
The plasma elimination half-life is typically 3-4 hours, but can be longer in patients with renal impairment.
Absorption
Approximately 40-50% orally absorbed. Absorption may be slightly prolonged by food but not significantly affected.
Metabolism
Cefixime is not extensively metabolized in the body. There are no active metabolites.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase the absorption and peak plasma levels of cefixime.
Carbamazepine
Concomitant administration may increase plasma levels of carbamazepine. Therapeutic drug monitoring of carbamazepine should be considered.
Oral Contraceptives
May decrease the effectiveness of oral contraceptives, although clinical significance is debated. Additional contraceptive methods may be advised.
Anticoagulants (e.g., Warfarin)
Increased prothrombin time (PT) and international normalized ratio (INR), leading to an increased risk of bleeding. Close monitoring of coagulation parameters is advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase the absorption and peak plasma levels of cefixime.
Carbamazepine
Concomitant administration may increase plasma levels of carbamazepine. Therapeutic drug monitoring of carbamazepine should be considered.
Oral Contraceptives
May decrease the effectiveness of oral contraceptives, although clinical significance is debated. Additional contraceptive methods may be advised.
Anticoagulants (e.g., Warfarin)
Increased prothrombin time (PT) and international normalized ratio (INR), leading to an increased risk of bleeding. Close monitoring of coagulation parameters is advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture. Refer to the specific packaging for expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections since its approval. Ongoing surveillance monitors antibiotic resistance patterns.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) during prolonged or high-dose therapy.
- Liver function tests (LFTs) if liver abnormalities are suspected.
Doctor Notes
- Advise patients to complete the full course of therapy to prevent resistance.
- Consider dose adjustment in patients with significant renal impairment.
- Be aware of potential interactions with anticoagulants; monitor INR closely.
Patient Guidelines
- Complete the entire course of medication as prescribed by your doctor, even if your symptoms improve.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe diarrhea, rash, or unusual symptoms to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Cefixime affects them.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Drink plenty of fluids unless otherwise advised by your doctor.
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Global Brand Names
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