Triocim
Generic Name
Cefixime
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triocim 200 mg capsule | ৳ 45.00 | ৳ 180.00 |
Description
Overview of the medicine
Triocim 200 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
200-400 mg daily as a single dose or in two divided doses for 7-14 days depending on the infection. For uncomplicated gonorrhea, a single 400 mg dose.
Elderly
No dosage adjustment needed unless severe renal impairment.
Renal_impairment
For creatinine clearance 21-60 mL/min: 300 mg daily. For creatinine clearance <20 mL/min: 200 mg daily.
How to Take
Triocim 200 mg Capsule can be taken with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) inside the bacterial cell wall. This leads to inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. The remainder is excreted via non-renal mechanisms, likely biliary excretion.
Half life
3 to 4 hours (range 2.5-6 hours)
Absorption
Approximately 40-50% orally absorbed. Absorption may be slightly delayed by food but total amount absorbed is not significantly affected.
Metabolism
Not significantly metabolized in the liver; limited metabolism known.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime concentrations.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding. Monitor PT/INR carefully.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime concentrations.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding. Monitor PT/INR carefully.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections. Ongoing research explores its role in emerging resistant strains.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with impaired renal function)
- Complete Blood Count (CBC) (for prolonged therapy)
- Prothrombin time/INR (if co-administered with anticoagulants)
Doctor Notes
- Counsel patients on the importance of completing the full course of antibiotics.
- Be aware of potential drug interactions, especially with anticoagulants.
- Monitor for signs of C. difficile-associated diarrhea, even weeks after treatment cessation.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine early, even if you feel better, to prevent recurrence of infection and antibiotic resistance.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution before driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Avoid self-medication with antibiotics.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Triocim Brand
Other medicines available under the same brand name
