Trixim
Generic Name
Cefixime 100 mg Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trixim 100 mg suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Trixim 100 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria. It is commonly prescribed for respiratory tract infections, urinary tract infections, otitis media, and pharyngitis/tonsillitis.
Uses & Indications
Dosage
Adults
Typically used in children. For adults unable to swallow tablets, dosage is usually 400 mg/day as a single dose or 200 mg every 12 hours.
Elderly
No specific dose adjustment required unless there is severe renal impairment.
Renal_impairment
Creatinine clearance 21-60 mL/min: 75% of standard dose. Creatinine clearance <20 mL/min: 50% of standard dose.
How to Take
Shake the bottle well before each use. Administer orally with a measuring spoon or oral syringe. Can be taken with or without food. Complete the full course of medication even if symptoms improve.
Mechanism of Action
Cefixime, like other beta-lactam antibiotics, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This prevents the cross-linking of peptidoglycan chains, leading to cell wall defects and eventual bacterial lysis and death.
Pharmacokinetics
Onset
Typically within 1 hour.
Excretion
Primarily renal (approximately 50% unchanged in urine), and some via biliary/fecal route.
Half life
3-4 hours (can be longer in renal impairment).
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but not significantly affect the extent.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (cross-allergenicity)
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Oral anticoagulants (e.g., Warfarin)
Cefixime may increase the anticoagulant effect, leading to increased risk of bleeding. Monitor INR/PT.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2°C-8°C) and discard after 7-14 days, as directed.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in low concentrations into breast milk. Use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (cross-allergenicity)
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Oral anticoagulants (e.g., Warfarin)
Cefixime may increase the anticoagulant effect, leading to increased risk of bleeding. Monitor INR/PT.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2°C-8°C) and discard after 7-14 days, as directed.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in low concentrations into breast milk. Use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years. Reconstituted suspension: 7-14 days (refrigerated).
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA/FDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections. Post-marketing surveillance continues to monitor safety.
Lab Monitoring
- Renal function tests (e.g., BUN, creatinine) in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) during prolonged therapy.
- INR/PT for patients on oral anticoagulants.
Doctor Notes
- Ensure patient completes the full course of antibiotics to prevent resistance.
- Advise parents on proper measurement and administration of suspension.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine even if you feel better, as this may lead to recurrent infection.
- Report any severe or persistent diarrhea to your doctor.
- Shake the suspension well before each use.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Trixim is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid these activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Ensure adequate hydration.
- Avoid self-medication.
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