Trixim
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trixim 200 mg capsule | ৳ 30.00 | ৳ 210.00 |
Description
Overview of the medicine
Trixim 200 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including those of the urinary tract, ear, throat, lungs, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
The usual adult dosage is 200 mg once daily or 100 mg twice daily. For severe or persistent infections, the dose may be increased to 400 mg once daily or 200 mg twice daily.
Elderly
No specific dose adjustment is required for elderly patients unless there is severe renal impairment. Renal function should be monitored.
Renal_impairment
For patients with creatinine clearance between 21-60 mL/min or on hemodialysis, the dose should be reduced to 200 mg once daily. For creatinine clearance <20 mL/min, the dose should be 100 mg once daily.
How to Take
Trixim capsule should be taken orally, with or without food. It is recommended to take it at about the same time each day.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Onset of antibacterial action typically occurs within 1-2 hours after oral administration.
Excretion
Approximately 50-55% of the absorbed dose is excreted unchanged in the urine over 24 hours. Renal excretion is the primary route.
Half life
The plasma half-life of cefixime is typically 3-4 hours, allowing for once or twice daily dosing.
Absorption
Oral bioavailability is 40-50%, and it is not significantly altered by food. Peak plasma concentrations are achieved within 2-6 hours after administration.
Metabolism
Cefixime undergoes limited metabolism in the liver; most of the absorbed drug is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
Concurrent use may prolong prothrombin time (INR) with or without clinical bleeding. Close monitoring of coagulation parameters is advised.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime. Monitor carbamazepine levels.
Oral Contraceptives
Some cephalosporins may reduce the efficacy of oral contraceptives, although this interaction is less commonly reported with cefixime.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis and peritoneal dialysis do not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
Concurrent use may prolong prothrombin time (INR) with or without clinical bleeding. Close monitoring of coagulation parameters is advised.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime. Monitor carbamazepine levels.
Oral Contraceptives
Some cephalosporins may reduce the efficacy of oral contraceptives, although this interaction is less commonly reported with cefixime.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis and peritoneal dialysis do not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across various bacterial infections in adults and children.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) should be monitored in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) should be monitored during prolonged therapy, as rare hematological effects may occur.
Doctor Notes
- Emphasize to patients the importance of completing the full course of antibiotic therapy to ensure bacterial eradication and prevent resistance.
- Consider renal function, especially in elderly patients or those with pre-existing kidney disease, and adjust the dose accordingly.
- Counsel patients on potential signs of C. difficile infection (e.g., severe, persistent diarrhea) and to seek immediate medical attention if these occur.
Patient Guidelines
- Take the entire course of medication as prescribed, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Do not share this medication with others, as it may not be suitable for their condition.
- Report any persistent or severe diarrhea to your doctor immediately, as it could be a sign of a more serious condition.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol consumption, especially if experiencing gastrointestinal side effects.
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