Trixim
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trixim 400 mg capsule | ৳ 50.00 | ৳ 300.00 |
Description
Overview of the medicine
Cefixime is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg every 12 hours. Duration depends on the infection.
Elderly
No specific dosage adjustment is necessary for elderly patients with normal renal function.
Renal_impairment
For creatinine clearance 21-60 mL/min, dose should be 300 mg daily. For creatinine clearance less than 20 mL/min, dose should be 200 mg daily.
How to Take
Trixim 400 mg capsule can be taken orally with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Cefixime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It prevents the cross-linkage of peptidoglycan chains, which is essential for bacterial cell wall integrity.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours post-dose.
Excretion
Primarily renal excretion (glomerular filtration and tubular secretion) of unchanged drug. Also, some biliary excretion.
Half life
Plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food does not significantly alter absorption.
Metabolism
Not extensively metabolized in the liver; about 50% of the absorbed dose is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime bioavailability.
Carbamazepine
Concomitant administration may result in increased carbamazepine plasma levels.
Oral contraceptives
May theoretically reduce the efficacy of oral contraceptives, although clinical significance is unclear.
Warfarin and other anticoagulants
May increase prothrombin time (INR), requiring careful monitoring and dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight, heat, and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Caution is advised when administered to a nursing woman, as it is excreted in human milk.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime bioavailability.
Carbamazepine
Concomitant administration may result in increased carbamazepine plasma levels.
Oral contraceptives
May theoretically reduce the efficacy of oral contraceptives, although clinical significance is unclear.
Warfarin and other anticoagulants
May increase prothrombin time (INR), requiring careful monitoring and dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight, heat, and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Caution is advised when administered to a nursing woman, as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the date of manufacture, specific to manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Monitor renal function (creatinine clearance) in patients with pre-existing renal impairment or during prolonged therapy.
- Monitor complete blood count (CBC) in patients receiving prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full antibiotic course to prevent bacterial resistance and treatment failure.
- Educate patients on potential signs of C. difficile-associated diarrhea and advise them to seek immediate medical attention if these symptoms occur.
- Consider renal function adjustment in elderly patients or those with known renal impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you start to feel better.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- If you experience severe diarrhea, especially if it's watery or bloody, contact your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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