Truso
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| truso 100 mg suspension | ৳ 135.00 | N/A |
Description
Overview of the medicine
Cefixime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections, including those of the urinary tract, ear, throat, and respiratory system. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typically used for adults in suspension form; adults usually take 400 mg once daily or 200 mg every 12 hours as tablet/capsule.
Elderly
No specific dose adjustment is generally required unless there is significant renal impairment.
Renal_impairment
For creatinine clearance < 60 mL/min, dosage adjustment is necessary. For CrCl 21-60 mL/min, total daily dose should be 75% of standard dose. For CrCl < 20 mL/min, total daily dose should be 50% of standard dose.
Children_6_months_to_12_years
8 mg/kg/day administered as a single dose or in two divided doses. Max dose 400 mg/day. (e.g., 10-15 kg: 2.5 mL twice daily; 15-20 kg: 3.75 mL twice daily; 20-25 kg: 5 mL twice daily).
How to Take
Administer orally with or without food. Shake the suspension well before each use. Use the provided measuring device (spoon or cup) for accurate dosing.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours.
Excretion
Approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours. Small amounts are excreted in bile and feces.
Half life
Average plasma half-life of 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food does not significantly alter absorption.
Metabolism
Not extensively metabolized in the body. About 10% may be metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- Patients with a history of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
Increases cefixime plasma concentrations by decreasing its renal excretion.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Warfarin and other Anticoagulants
May increase prothrombin time (PT) with or without bleeding. Close monitoring of coagulation parameters is recommended.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C). Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in lactating mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- Patients with a history of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
Increases cefixime plasma concentrations by decreasing its renal excretion.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Warfarin and other Anticoagulants
May increase prothrombin time (PT) with or without bleeding. Close monitoring of coagulation parameters is recommended.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C). Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24 months from manufacturing date. Reconstituted suspension: 7 days when refrigerated (2-8°C).
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, including pediatric populations. Studies have confirmed its bactericidal activity and favorable pharmacokinetic profile.
Lab Monitoring
- Periodic assessment of renal function is advisable during prolonged therapy.
- Monitor coagulation parameters (e.g., PT/INR) if co-administered with anticoagulants.
Doctor Notes
- Emphasize patient compliance to complete the full antibiotic course to prevent resistance.
- Counsel patients on potential for C. difficile-associated diarrhea and advise seeking medical attention for severe, persistent diarrhea.
- Review renal function, especially in elderly patients or those with pre-existing kidney impairment, for appropriate dose adjustment.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Shake the suspension well before each administration.
- Report any severe or persistent diarrhea to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness in some individuals. Patients should be cautious when driving or operating machinery until they know how Cefixime affects them.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea.
- Avoid self-medication with antibiotics to prevent antibiotic resistance.
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