Urodin
Generic Name
Solifenacin Succinate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urodin 250 mg capsule | ৳ 7.00 | ৳ 49.00 |
| urodin 500 mg capsule | ৳ 12.00 | ৳ 84.00 |
| urodin 125 mg suspension | ৳ 80.00 | N/A |
| urodin 125 mg pediatric drop | ৳ 50.00 | N/A |
Description
Overview of the medicine
Urodin (Solifenacin Succinate) is used to treat symptoms of overactive bladder (OAB) such as urinary urgency, frequency, and urge incontinence.
Uses & Indications
Dosage
Adults
The recommended starting dose is 5 mg once daily. If needed, the dose may be increased to 10 mg once daily.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), the maximum dose should be 5 mg once daily.
Hepatic_impairment
For patients with moderate hepatic impairment (Child-Pugh B), the maximum dose should be 5 mg once daily. Not recommended for severe hepatic impairment (Child-Pugh C).
How to Take
Take orally with water, with or without food. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
It is a competitive muscarinic receptor antagonist that selectively blocks M3 receptors in the bladder, thereby reducing involuntary contractions of the detrusor muscle.
Pharmacokinetics
Onset
Clinical effects are typically observed within one week of starting treatment, with full efficacy seen within 4-8 weeks.
Excretion
Approximately 69% of the dose is excreted in the urine and 23% in the feces.
Half life
The elimination half-life is approximately 45-68 hours.
Absorption
Well absorbed after oral administration, bioavailability is approximately 90%. Peak plasma concentrations (Tmax) are reached within 3 to 8 hours.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment (Child-Pugh C)
- Patients undergoing hemodialysis
- Known hypersensitivity to solifenacin succinate or any component of the formulation.
Drug Interactions
0
Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Reduce Urodin dose to 5 mg.
1
CYP3A4 inducers (e.g., rifampicin, phenytoin): May decrease solifenacin exposure.
2
Other anticholinergic drugs: May enhance anticholinergic side effects.
3
Cholinergic receptor agonists: May reduce the effect of cholinergic agonists.
4
Drugs that prolong QT interval: Use with caution as solifenacin may prolong QT interval.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects such as dry mouth, blurred vision, constipation, urinary retention, tachycardia, and mydriasis. Treatment should be symptomatic and supportive, including gastric lavage, activated charcoal, and if severe CNS effects occur, physostigmine.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if solifenacin is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment (Child-Pugh C)
- Patients undergoing hemodialysis
- Known hypersensitivity to solifenacin succinate or any component of the formulation.
Drug Interactions
0
Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Reduce Urodin dose to 5 mg.
1
CYP3A4 inducers (e.g., rifampicin, phenytoin): May decrease solifenacin exposure.
2
Other anticholinergic drugs: May enhance anticholinergic side effects.
3
Cholinergic receptor agonists: May reduce the effect of cholinergic agonists.
4
Drugs that prolong QT interval: Use with caution as solifenacin may prolong QT interval.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects such as dry mouth, blurred vision, constipation, urinary retention, tachycardia, and mydriasis. Treatment should be symptomatic and supportive, including gastric lavage, activated charcoal, and if severe CNS effects occur, physostigmine.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if solifenacin is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, depending on specific formulation and packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA, FDA
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of solifenacin in treating overactive bladder symptoms. Studies typically focus on reducing micturition frequency, urgency, and incontinence episodes.
Doctor Notes
- Advise patients on lifestyle modifications.
- Monitor for anticholinergic side effects, especially in elderly and those with pre-existing conditions (e.g., glaucoma, cardiac issues).
- Consider dose reduction in patients with moderate renal or hepatic impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any severe or persistent side effects to your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
Urodin may cause blurred vision, dizziness, or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise.
- Avoid excessive caffeine and alcohol, as they can worsen bladder symptoms.
- Practice bladder training techniques as advised by your healthcare provider.
- Manage fluid intake, especially before bedtime.
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