Vastigro
Generic Name
Vastigrol Hydrochloride
Manufacturer
Apex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vastigro 15 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Vastigro 15 mg Capsule is an antiemetic and prokinetic agent used to relieve nausea and vomiting and to improve gastric motility.
Uses & Indications
Dosage
Adults
15 mg capsule once daily, preferably before meals. Maximum 30 mg/day.
Elderly
Lower doses may be considered; e.g., 10 mg once daily. Adjust based on renal function.
Renal_impairment
Reduce dose to 10 mg once daily for moderate to severe impairment. Avoid in end-stage renal disease.
How to Take
Take the capsule whole with a glass of water, preferably 15-30 minutes before meals. Do not crush or chew.
Mechanism of Action
Vastigrol Hydrochloride selectively blocks peripheral dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and in the gastrointestinal tract, leading to antiemetic and prokinetic effects.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily excreted via urine (65%) and feces (35%).
Half life
Approximately 8-10 hours
Absorption
Rapidly absorbed from the GI tract; bioavailability around 60-75%.
Metabolism
Extensively metabolized in the liver via CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to Vastigrol or any excipients
- Pheochromocytoma
- GI hemorrhage, mechanical obstruction, or perforation
- Prolactin-dependent tumors
- Severe hepatic impairment
Drug Interactions
Anticholinergics
May antagonize the prokinetic effect of Vastigrol.
Ketoconazole, Erythromycin
Increased plasma levels of Vastigrol due to CYP3A4 inhibition, increasing risk of QT prolongation.
QT-prolonging drugs (e.g., Amiodarone, Cisapride)
Increased risk of cardiac arrhythmias.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, disorientation, extrapyramidal reactions. Management is symptomatic and supportive, including gastric lavage and activated charcoal. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Vastigrol or any excipients
- Pheochromocytoma
- GI hemorrhage, mechanical obstruction, or perforation
- Prolactin-dependent tumors
- Severe hepatic impairment
Drug Interactions
Anticholinergics
May antagonize the prokinetic effect of Vastigrol.
Ketoconazole, Erythromycin
Increased plasma levels of Vastigrol due to CYP3A4 inhibition, increasing risk of QT prolongation.
QT-prolonging drugs (e.g., Amiodarone, Cisapride)
Increased risk of cardiac arrhythmias.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, disorientation, extrapyramidal reactions. Management is symptomatic and supportive, including gastric lavage and activated charcoal. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Patent protected
Clinical Trials
Phase III clinical trials demonstrated significant reduction in nausea and vomiting scores compared to placebo, with an acceptable safety profile.
Lab Monitoring
- Electrolyte levels (Potassium, Magnesium)
- ECG (especially in at-risk patients)
- Liver function tests (for long-term use)
Doctor Notes
- Emphasize short-term use and lowest effective dose.
- Monitor for cardiac symptoms and neurological adverse effects.
- Caution in patients with cardiac risk factors or concomitant QT-prolonging drugs.
Patient Guidelines
- Take exactly as prescribed.
- Do not take more than the recommended dose.
- Report any unusual side effects to your doctor.
- Avoid alcohol while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how Vastigro affects you.
Lifestyle Advice
- Maintain a healthy diet to support digestive health.
- Stay hydrated.
- Avoid spicy or fatty foods if they trigger nausea/vomiting.
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