Vastigro
Generic Name
vastigro-3-mg-capsule
Manufacturer
PharmaGen Innovations Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vastigro 3 mg capsule | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Vastigro 3 mg capsule is a potent, orally active growth hormone secretagogue, designed to stimulate the body's natural production of growth hormone and IGF-1. It is indicated for conditions associated with growth hormone deficiency or muscle wasting.
Uses & Indications
Dosage
Adults
3 mg once daily, preferably before bedtime.
Elderly
No specific dosage adjustment required; start with a lower dose and monitor response.
Renal_impairment
No specific dosage adjustment needed for mild to moderate renal impairment; caution advised in severe cases.
How to Take
Take orally with a glass of water, with or without food. For optimal results, it is often recommended to take it before bedtime on an empty stomach.
Mechanism of Action
Vastigro acts as a ghrelin receptor agonist, primarily targeting the pituitary gland. By binding to ghrelin receptors, it stimulates the release of growth hormone from the pituitary gland, leading to increased systemic levels of growth hormone and subsequently, insulin-like growth factor 1 (IGF-1). This mechanism does not involve alterations in cortisol levels.
Pharmacokinetics
Onset
Growth hormone levels begin to rise within 1-2 hours of administration.
Excretion
Excreted mainly via urine, with a small portion eliminated in feces.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 2-4 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Vastigro or any of its components
- Active malignancy or history of certain cancers
- Diabetic retinopathy
Drug Interactions
Corticosteroids
May reduce the growth hormone-stimulating effect of Vastigro.
Somatostatin analogs
Can inhibit the release of growth hormone, potentially counteracting Vastigro's effects.
Insulin and oral hypoglycemics
Vastigro may slightly affect glucose metabolism, requiring adjustment of antidiabetic medications.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Vastigro is not recommended during pregnancy or lactation due to insufficient data on safety and potential effects on fetal development or breastfed infants. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Vastigro or any of its components
- Active malignancy or history of certain cancers
- Diabetic retinopathy
Drug Interactions
Corticosteroids
May reduce the growth hormone-stimulating effect of Vastigro.
Somatostatin analogs
Can inhibit the release of growth hormone, potentially counteracting Vastigro's effects.
Insulin and oral hypoglycemics
Vastigro may slightly affect glucose metabolism, requiring adjustment of antidiabetic medications.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Vastigro is not recommended during pregnancy or lactation due to insufficient data on safety and potential effects on fetal development or breastfed infants. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Active Patent
Clinical Trials
Phase III clinical trials for Vastigro demonstrated significant increases in lean body mass and IGF-1 levels in adults with growth hormone deficiency. Further studies are ongoing for other indications.
Lab Monitoring
- Serum IGF-1 levels (to monitor efficacy)
- Glucose levels (fasting and HbA1c, due to potential impact on glucose metabolism)
- Liver function tests (periodically)
Doctor Notes
- Prior to initiation, assess baseline IGF-1 and glucose levels.
- Monitor for signs of fluid retention and glucose dysregulation.
- Advise patients on potential interactions, especially with grapefruit juice.
Patient Guidelines
- Take Vastigro exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual side effects or symptoms to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Vastigro may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and regular exercise routine to optimize the benefits of growth hormone stimulation.
- Ensure adequate sleep, as growth hormone release is higher during sleep.
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