Velofix
Generic Name
Cefixime
Manufacturer
Unimed Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| velofix 200 mg capsule | ৳ 40.00 | ৳ 240.00 |
Description
Overview of the medicine
Velofix 200 mg Capsule contains Cefixime, which is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
200 mg once daily or 100 mg twice daily. For severe infections, 200 mg twice daily.
Elderly
No dosage adjustment is generally required unless renal function is significantly impaired.
Renal_impairment
For creatinine clearance 21-60 mL/min, dosage should be 75% of the standard dose. For creatinine clearance <20 mL/min, dosage should be 50% of the standard dose.
How to Take
Take orally with or without food. To minimize gastrointestinal upset, it can be taken with food.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bactericidal activity. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the final transpeptidation step of peptidoglycan synthesis.
Pharmacokinetics
Onset
Within 1 hour (for antibacterial effect)
Excretion
Primarily excreted unchanged in the urine (about 50%) and bile (about 10%).
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can slightly delay absorption but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized; some formation of inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR closely.
Probenecid
May increase Cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Concomitant administration has been reported to increase plasma carbamazepine levels.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR closely.
Probenecid
May increase Cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Concomitant administration has been reported to increase plasma carbamazepine levels.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Expired, generic versions widely available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Cefixime's efficacy and safety for indicated bacterial infections.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with impaired renal function or on prolonged therapy
- Complete blood count (CBC) during prolonged therapy
- Liver function tests (LFTs) if clinically indicated
Doctor Notes
- Ensure patient is not hypersensitive to cephalosporins or penicillins.
- Adjust dose in renal impairment. Monitor renal function in elderly or renally impaired patients.
- Advise patients to complete the full course of treatment to prevent resistance.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Do not share your medicine with others.
- Inform your doctor if you experience severe diarrhea or unusual side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain good hygiene to prevent spread of infection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Velofix Brand
Other medicines available under the same brand name
