velofix
Generic Name
Cefixime
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| velofix 400 mg capsule | ৳ 55.00 | ৳ 220.00 |
Description
Overview of the medicine
Velofix 400 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
400 mg once daily or 200 mg every 12 hours, depending on the infection. Duration typically 7-14 days.
Elderly
Dosage adjustments generally not necessary unless severe renal impairment exists.
Renal_impairment
Dosage reduction recommended for creatinine clearance < 60 mL/min.
How to Take
Take the capsule orally with or without food. Complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Peak plasma concentrations achieved 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion (about 50%), and also in bile.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed; food may delay but not significantly alter absorption.
Metabolism
Not extensively metabolized; some metabolites may be formed but active drug predominates.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe penicillin allergy
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, requiring close monitoring.
Carbamazepine
Cefixime may increase carbamazepine levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated; otherwise, supportive treatment is recommended. Hemodialysis and peritoneal dialysis are not effective.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe penicillin allergy
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, requiring close monitoring.
Carbamazepine
Cefixime may increase carbamazepine levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated; otherwise, supportive treatment is recommended. Hemodialysis and peritoneal dialysis are not effective.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefixime for approved indications.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) if long-term therapy or renal impairment.
- Complete blood count (CBC) if prolonged use.
Doctor Notes
- Advise patients to complete the entire course of therapy to prevent antibiotic resistance.
- Monitor for signs of hypersensitivity reactions, especially in patients with penicillin allergy.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Do not share this medication with others.
- Inform your doctor about any unusual side effects.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
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