Vifas
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vifas 180 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Vifas 180 mg Tablet contains Fexofenadine Hydrochloride, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It effectively reduces sneezing, runny nose, itchy watery eyes, and skin itching.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis and chronic idiopathic urticaria: 180 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients, but monitoring of renal function is advisable.
Renal_impairment
For patients with impaired renal function, a starting dose of 60 mg once daily is recommended. Consult your doctor for specific advice.
How to Take
Take the tablet orally with water, preferably before a meal. Do not take with fruit juices as they may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It blocks the action of histamine, a natural substance in the body that causes allergic symptoms, by binding to H1 receptors. This prevents histamine from activating these receptors, thereby reducing allergic responses.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in the feces (approximately 80%) and urine (approximately 11%) as unchanged drug.
Half life
Approximately 14-16 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours.
Metabolism
Minimally metabolized; approximately 5% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
Drug Interactions
Erythromycin or Ketoconazole
Can increase plasma levels of fexofenadine. Clinical significance is usually minimal, but caution is advised.
Grapefruit juice, orange juice, apple juice
Can significantly reduce the bioavailability of fexofenadine. Avoid taking fexofenadine with these fruit juices.
Antacids (containing aluminum and magnesium)
May decrease the absorption of fexofenadine. It is recommended to separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. In case of an overdose, symptomatic and supportive measures should be initiated. Contact a poison control center or seek immediate medical attention.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Fexofenadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor before use.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
Drug Interactions
Erythromycin or Ketoconazole
Can increase plasma levels of fexofenadine. Clinical significance is usually minimal, but caution is advised.
Grapefruit juice, orange juice, apple juice
Can significantly reduce the bioavailability of fexofenadine. Avoid taking fexofenadine with these fruit juices.
Antacids (containing aluminum and magnesium)
May decrease the absorption of fexofenadine. It is recommended to separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. In case of an overdose, symptomatic and supportive measures should be initiated. Contact a poison control center or seek immediate medical attention.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Fexofenadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved (Generic)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic urticaria. Ongoing research explores its potential in other allergic or inflammatory conditions.
Lab Monitoring
- Routine laboratory monitoring is generally not required during treatment with Fexofenadine.
Doctor Notes
- Advise patients on the importance of avoiding fruit juices around the time of fexofenadine administration.
- Consider dose adjustment in patients with significant renal impairment.
- Fexofenadine is generally safe for patients requiring non-sedating antihistamines, but individual patient response to sedation should be monitored.
Patient Guidelines
- Take the tablet exactly as prescribed by your doctor.
- Do not take with fruit juices (grapefruit, orange, apple).
- Report any unusual or severe side effects to your doctor.
- Do not exceed the recommended dose.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is generally non-drowsy, but individual responses vary. If you experience drowsiness or dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens if possible.
- Maintain adequate hydration.
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