Vifas
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vifas 60 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Vifas 60 mg tablet contains Fexofenadine Hydrochloride, a second-generation antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria. It is a non-drowsy antihistamine for day-time use.
Uses & Indications
Dosage
Adults
Seasonal Allergic Rhinitis: 60 mg twice daily or 180 mg once daily. Chronic Idiopathic Urticaria: 60 mg twice daily.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in elderly patients with impaired renal function.
Renal_impairment
For adults with impaired renal function, the recommended starting dose is 60 mg once daily.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juices (grapefruit, orange, apple) as they may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It prevents the effects of histamine released during allergic reactions by blocking histamine H1 receptors, thereby reducing symptoms like sneezing, runny nose, itchy eyes, and skin rash.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted unchanged in the feces (approximately 80%) and urine (approximately 11%).
Half life
Approximately 11-15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2-3 hours.
Metabolism
Minimally metabolized (approximately 5% of the dose) in the liver. Primarily by CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
May increase plasma concentrations of fexofenadine, but this interaction is generally not considered clinically significant.
Antacids containing aluminum and magnesium
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Management should be symptomatic and supportive, including general supportive measures and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether fexofenadine is excreted in human breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
May increase plasma concentrations of fexofenadine, but this interaction is generally not considered clinically significant.
Antacids containing aluminum and magnesium
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Management should be symptomatic and supportive, including general supportive measures and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether fexofenadine is excreted in human breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic urticaria across various populations, including comparisons to placebo and other antihistamines.
Lab Monitoring
- No specific routine laboratory monitoring is typically required for fexofenadine.
Doctor Notes
- Counsel patients on the importance of avoiding fruit juices due to reduced absorption.
- Advise patients that while generally non-sedating, individual responses to drowsiness can vary.
- Review concurrent medications for potential interactions, especially antacids.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Avoid consuming fruit juices (grapefruit, orange, apple) within 2 hours of taking fexofenadine.
- Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is generally considered non-sedating, but some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hydration and a healthy lifestyle.
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