Vigorex
Generic Name
Sildenafil
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vigorex 25 mg tablet | ৳ 20.06 | ৳ 100.30 |
Description
Overview of the medicine
Vigorex 25 mg Tablet is a medication used to treat erectile dysfunction (impotence) in men. It helps to achieve and maintain an erection sufficient for sexual activity by increasing blood flow to the penis.
Uses & Indications
Dosage
Adults
For most patients, the starting dose is 25 mg taken orally, as needed, approximately 1 hour before sexual activity. It may be taken between 30 minutes to 4 hours before sexual activity. The dose may be adjusted based on individual response and tolerability. Do not exceed one dose per 24 hours.
Elderly
No dose adjustment is generally required, but consideration should be given to a lower starting dose (e.g., 25 mg) due to potential age-related decrease in clearance and increased sensitivity to side effects.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Take Vigorex 25 mg Tablet orally with a glass of water, approximately 30-60 minutes before sexual activity. It can be taken with or without food, but a high-fat meal may delay the onset of action.
Mechanism of Action
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It enhances the effects of nitric oxide, leading to increased cGMP levels in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the penis.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Excreted predominantly as metabolites in the feces (approximately 80%) and, to a lesser extent, in the urine (approximately 13%).
Half life
Approximately 3-5 hours
Absorption
Rapidly absorbed. Absolute bioavailability is approximately 41%. Peak plasma concentrations reached within 30-120 minutes (median 60 minutes) in the fasted state.
Metabolism
Primarily metabolized by hepatic microsomal isoenzymes CYP3A4 (major route) and CYP2C9 (minor route).
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) in any form (oral, sublingual, transdermal, injectable) due to potentiation of hypotensive effects.
- Hypersensitivity to Sildenafil or any component of the tablet.
- Concomitant use with guanylate cyclase stimulators like Riociguat.
- Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) regardless of previous PDE5 inhibitor exposure.
- Severe cardiovascular disorders (e.g., unstable angina, severe heart failure), recent stroke or myocardial infarction.
Drug Interactions
Alcohol
Excessive alcohol consumption may increase the risk of side effects like dizziness and headache.
Nitrates
Potentiation of hypotensive effects, leading to severe and potentially fatal hypotension. Contraindicated.
Riociguat
Contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., Doxazosin, Tamsulosin)
Risk of symptomatic hypotension (dizziness, lightheadedness) when co-administered. Start Sildenafil at 25 mg and ensure patient is stable on alpha-blocker therapy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Ritonavir)
Increased plasma concentrations of Sildenafil. A lower starting dose of Sildenafil may be considered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg resulted in similar adverse events as seen at lower doses, but with increased incidence and severity. In case of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly protein bound and not significantly excreted in urine.
Pregnancy & Lactation
Not indicated for use in women. No relevant data are available regarding the use of Sildenafil in pregnant or lactating women.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) in any form (oral, sublingual, transdermal, injectable) due to potentiation of hypotensive effects.
- Hypersensitivity to Sildenafil or any component of the tablet.
- Concomitant use with guanylate cyclase stimulators like Riociguat.
- Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) regardless of previous PDE5 inhibitor exposure.
- Severe cardiovascular disorders (e.g., unstable angina, severe heart failure), recent stroke or myocardial infarction.
Drug Interactions
Alcohol
Excessive alcohol consumption may increase the risk of side effects like dizziness and headache.
Nitrates
Potentiation of hypotensive effects, leading to severe and potentially fatal hypotension. Contraindicated.
Riociguat
Contraindicated due to risk of severe hypotension.
Alpha-blockers (e.g., Doxazosin, Tamsulosin)
Risk of symptomatic hypotension (dizziness, lightheadedness) when co-administered. Start Sildenafil at 25 mg and ensure patient is stable on alpha-blocker therapy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Ritonavir)
Increased plasma concentrations of Sildenafil. A lower starting dose of Sildenafil may be considered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg resulted in similar adverse events as seen at lower doses, but with increased incidence and severity. In case of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly protein bound and not significantly excreted in urine.
Pregnancy & Lactation
Not indicated for use in women. No relevant data are available regarding the use of Sildenafil in pregnant or lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Patent expired, generic versions available
Clinical Trials
Sildenafil has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of erectile dysfunction across various patient populations.
Lab Monitoring
- No specific routine lab monitoring is required for Sildenafil use.
Doctor Notes
- Assess the patient's cardiovascular status thoroughly before prescribing Sildenafil, especially for patients with pre-existing heart conditions.
- Counsel patients on the absolute contraindication with nitrates and alpha-blockers to prevent severe hypotensive episodes.
- Advise patients to seek immediate medical attention for priapism (erection lasting >4 hours) or sudden loss of vision/hearing.
- Emphasize that Sildenafil is not an aphrodisiac and requires sexual stimulation for efficacy.
Patient Guidelines
- Do not take Vigorex-25-mg-tablet more than once in 24 hours.
- Seek immediate medical attention if you experience an erection lasting more than 4 hours (priapism).
- Never take this medicine if you are using nitrate-containing drugs.
- Report any sudden changes in vision or hearing to your doctor immediately.
- Be aware that this medicine does not protect against sexually transmitted diseases (STDs).
Missed Dose Advice
Vigorex 25 mg Tablet is taken on an as-needed basis, so a missed dose protocol does not typically apply. Take it only when intended for sexual activity.
Driving Precautions
Vigorex 25 mg Tablet may cause dizziness or visual disturbances. Patients should be aware of how they react to the medicine before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, to support overall cardiovascular health and potentially improve erectile function.
- Avoid excessive alcohol consumption as it can worsen erectile dysfunction and increase the risk of side effects like dizziness and hypotension.
- Quit smoking, as smoking is a significant risk factor for ED and cardiovascular disease.
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