Vigorex
Generic Name
Sildenafil Citrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vigorex 50 mg tablet | ৳ 30.10 | ৳ 150.50 |
Description
Overview of the medicine
Vigorex 50 mg Tablet contains Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, used for the treatment of erectile dysfunction (ED) in men. It helps to achieve and maintain an erection sufficient for satisfactory sexual activity.
Uses & Indications
Dosage
Adults
The recommended dose is 50 mg taken approximately 1 hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.
Elderly
A starting dose of 25 mg should be considered in elderly patients (≥65 years) due to reduced clearance and increased plasma levels.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Take Vigorex 50 mg Tablet orally approximately 1 hour before sexual activity. It can be taken with or without food. However, a high-fat meal may delay the onset of action.
Mechanism of Action
Sildenafil inhibits phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By inhibiting PDE5, Sildenafil increases cGMP levels, leading to relaxation of smooth muscles and increased blood flow into the penis, resulting in an erection. It requires sexual stimulation to be effective.
Pharmacokinetics
Onset
Typically within 30-60 minutes.
Excretion
Excreted predominantly as metabolites in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).
Half life
The terminal half-life is approximately 3-5 hours.
Absorption
Rapidly absorbed after oral administration, with mean absolute bioavailability of about 41%. Peak plasma concentrations are reached within 30-120 minutes (median 60 minutes) after oral dosing in the fasted state.
Metabolism
Primarily metabolized by hepatic microsomal isoenzymes CYP3A4 (major route) and CYP2C9 (minor route). The major circulating metabolite, N-desmethyl sildenafil, has about 50% of the potency of the parent drug.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form, as it may cause a profound drop in blood pressure.
- Concomitant use with guanylate cyclase stimulators (e.g., riociguat).
- Hypersensitivity to Sildenafil or any component of the tablet.
- Patients with severe cardiovascular events (e.g., recent myocardial infarction or stroke).
- Severe hepatic impairment.
- Hypotension (blood pressure <90/50 mmHg).
- Known hereditary degenerative retinal disorders (e.g., retinitis pigmentosa).
Drug Interactions
Nitrates
Contraindicated. Potentiates the hypotensive effect of nitrates, leading to severe hypotension.
Riociguat
Contraindicated. Concomitant use may cause symptomatic hypotension.
Alpha-blockers
Risk of symptomatic hypotension due to additive vasodilatory effects. Initiate Sildenafil at 25 mg with caution in patients taking alpha-blockers.
CYP3A4 Inhibitors (e.g., Ritonavir, Ketoconazole, Erythromycin)
May significantly increase Sildenafil plasma levels. A lower starting dose (25 mg) of Sildenafil is recommended when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg have been administered, resulting in adverse events similar to those seen at lower doses but generally more pronounced. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly bound to plasma proteins and not significantly excreted in the urine.
Pregnancy & Lactation
Vigorex (Sildenafil) is not indicated for use in women. Therefore, information regarding pregnancy and lactation is not applicable.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form, as it may cause a profound drop in blood pressure.
- Concomitant use with guanylate cyclase stimulators (e.g., riociguat).
- Hypersensitivity to Sildenafil or any component of the tablet.
- Patients with severe cardiovascular events (e.g., recent myocardial infarction or stroke).
- Severe hepatic impairment.
- Hypotension (blood pressure <90/50 mmHg).
- Known hereditary degenerative retinal disorders (e.g., retinitis pigmentosa).
Drug Interactions
Nitrates
Contraindicated. Potentiates the hypotensive effect of nitrates, leading to severe hypotension.
Riociguat
Contraindicated. Concomitant use may cause symptomatic hypotension.
Alpha-blockers
Risk of symptomatic hypotension due to additive vasodilatory effects. Initiate Sildenafil at 25 mg with caution in patients taking alpha-blockers.
CYP3A4 Inhibitors (e.g., Ritonavir, Ketoconazole, Erythromycin)
May significantly increase Sildenafil plasma levels. A lower starting dose (25 mg) of Sildenafil is recommended when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In studies with healthy volunteers, single doses up to 800 mg have been administered, resulting in adverse events similar to those seen at lower doses but generally more pronounced. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly bound to plasma proteins and not significantly excreted in the urine.
Pregnancy & Lactation
Vigorex (Sildenafil) is not indicated for use in women. Therefore, information regarding pregnancy and lactation is not applicable.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to batch.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (internationally and in Bangladesh)
Patent Status
Off-patent (generic versions available)
Clinical Trials
Sildenafil has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of erectile dysfunction.
Lab Monitoring
- No specific routine laboratory monitoring is required for Sildenafil use in erectile dysfunction. However, patients with underlying cardiovascular conditions should be carefully evaluated before starting treatment.
Doctor Notes
- Thorough cardiovascular assessment is crucial before prescribing Sildenafil, especially in patients with pre-existing heart conditions.
- Counsel patients on the proper administration, potential side effects, and the importance of not exceeding the recommended dose.
- Emphasize that Sildenafil should not be used with nitrates or guanylate cyclase stimulators due to severe hypotensive risk.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not take more than one dose in 24 hours.
- Seek immediate medical attention if you experience an erection lasting more than 4 hours or sudden vision/hearing loss.
- Inform your doctor about all other medications you are taking, especially nitrates or alpha-blockers.
- This medicine does not protect against sexually transmitted diseases.
Missed Dose Advice
Vigorex is taken on an 'as needed' basis, so there is no regular dosing schedule. If you plan to have sexual activity, take your dose as directed. Do not take more than one dose in 24 hours.
Driving Precautions
Vigorex may cause dizziness or visual disturbances (e.g., blurred vision). Patients should be aware of how they react to Vigorex before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, which can improve overall cardiovascular health and potentially aid in erectile function.
- Avoid excessive alcohol consumption, as it can temporarily impair the ability to get an erection.
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