Adults

For common intestinal worms (e.g., Ascaris, hookworm, pinworm, whipworm): 10 ml (400 mg) as a single dose. For Strongyloidiasis or Taeniasis: 10 ml (400 mg) once daily for 3 days. For other specific infestations, follow doctor's advice.

Elderly

No specific dose adjustment required, but use with caution in patients with hepatic impairment. Dosage should be determined by a healthcare professional based on individual condition.

Renal_impairment

No specific dose adjustment is generally required for patients with renal impairment, but caution is advised in severe cases.

Hepatic_impairment

Use with caution. As albendazole is extensively metabolized in the liver, reduced doses or extended dosing intervals may be necessary. Liver function should be monitored.

Onset

Variable, generally within 24-48 hours for intestinal worms. Effects on tissue-dwelling parasites may take longer.

Excretion

Primarily excreted via urine as metabolites (<1% as unchanged drug); some excretion in bile.

Half life

Albendazole sulfoxide (active metabolite): 8-12 hours.

Absorption

Poorly absorbed from the gastrointestinal tract (<5%). Absorption is significantly increased when taken with a fatty meal.

Metabolism

Rapidly and extensively metabolized in the liver to its primary active metabolite, albendazole sulfoxide.

Theophylline

Albendazole may cause a slight increase in plasma concentrations of theophylline; monitor theophylline levels if co-administered.

Praziquantel, Dexamethasone, Cimetidine

May increase plasma concentrations of albendazole sulfoxide, potentially enhancing its therapeutic effects but also increasing side effects.