Adults

For most common intestinal worms (Ascaris, Hookworm, Pinworm, Whipworm): 400 mg (equivalent to 40 ml of 50 mg/5 ml suspension) as a single dose. For Strongyloidiasis or Taeniasis: 400 mg (40 ml) once daily for 3 days. For Hydatid disease or Neurocysticercosis: 400 mg (40 ml) twice daily with meals for 8-30 days, or longer depending on the condition.

Elderly

Dosage adjustment is generally not required for elderly patients unless there is significant hepatic or renal impairment.

Renal_impairment

No specific dose adjustment is considered necessary for patients with renal impairment, but caution is advised in severe cases.

Onset

Onset of action is variable, depending on the type of worm and infection site. Therapeutic effects typically manifest within a few days.

Excretion

Albendazole and its metabolites are primarily excreted via bile and, to a lesser extent, urine.

Half life

The plasma half-life of albendazole sulfoxide (the active metabolite) is approximately 8-12 hours.

Absorption

Poorly absorbed from the gastrointestinal tract (<5%). Absorption is significantly increased when taken with fatty meals.

Metabolism

Extensively undergoes first-pass metabolism in the liver to its primary active metabolite, albendazole sulfoxide, which is then further metabolized to inactive sulfone.

Ritonavir

May reduce the exposure of albendazole sulfoxide.

Cimetidine

Increases plasma concentrations of albendazole sulfoxide.

Praziquantel

Increases plasma concentrations of albendazole sulfoxide.

Theophylline

Albendazole may decrease theophylline clearance; monitor theophylline levels.

Dexamethasone

Increases plasma concentrations of albendazole sulfoxide.