Xadu
Generic Name
Xadolam 20 mg Tablet
Manufacturer
Alpha Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xadu 20 mg tablet | ৳ 200.00 | ৳ 2,000.00 |
Description
Overview of the medicine
Xadu 20 mg Tablet is used to treat depression, anxiety disorders, and panic disorder. It helps to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to 20 mg once daily after 1 week. Maximum dose 40 mg/day.
Elderly
Lower initial dose of 5 mg once daily, carefully titrated. Maximum recommended dose 20 mg/day.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Xadolam, as an SSRI, selectively inhibits the reuptake of serotonin by neurons, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission.
Pharmacokinetics
Onset
Initial effects seen in 1-2 weeks; full therapeutic effect within 4-6 weeks.
Excretion
Mainly excreted via urine (renal), with some fecal excretion.
Half life
Approximately 15-20 hours.
Absorption
Well absorbed orally; peak plasma concentrations reached within 4-6 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Xadolam or any component of the formulation
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI
Drug Interactions
MAOIs
Increased risk of serotonin syndrome. Concomitant use is contraindicated.
Warfarin
May increase the anticoagulant effect of warfarin, requiring INR monitoring.
Tricyclic Antidepressants (TCAs)
May increase plasma levels of TCAs.
Other Serotonergic Drugs (e.g., Triptans, Tramadol)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, tremor, somnolence, and tachycardia. Management involves symptomatic and supportive care, maintaining airway, and gastric lavage if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Small amounts may pass into breast milk; consult physician before breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Xadolam or any component of the formulation
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI
Drug Interactions
MAOIs
Increased risk of serotonin syndrome. Concomitant use is contraindicated.
Warfarin
May increase the anticoagulant effect of warfarin, requiring INR monitoring.
Tricyclic Antidepressants (TCAs)
May increase plasma levels of TCAs.
Other Serotonergic Drugs (e.g., Triptans, Tramadol)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, tremor, somnolence, and tachycardia. Management involves symptomatic and supportive care, maintaining airway, and gastric lavage if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Small amounts may pass into breast milk; consult physician before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Protected
Clinical Trials
Xadu underwent extensive Phase III clinical trials demonstrating efficacy and safety in major depressive disorder and generalized anxiety disorder. Post-marketing surveillance is ongoing.
Lab Monitoring
- Baseline and periodic liver function tests (LFTs) for patients with hepatic impairment.
- Sodium levels, especially in elderly or those on diuretics.
Doctor Notes
- Counsel patients on potential delayed onset of therapeutic effect and importance of adherence.
- Monitor for suicidality, especially in pediatric and young adult patients, particularly during initial therapy or dose changes.
- Gradual tapering is crucial to avoid withdrawal symptoms when discontinuing treatment.
Patient Guidelines
- Do not stop taking Xadu suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
- Report any worsening of depression, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
- It may take several weeks for the full therapeutic effect to be noticed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, drowsiness, or blurred vision. Patients should be cautious when driving or operating machinery until they know how Xadu affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking Xadu, as it may increase side effects.
- Maintain a healthy diet and exercise regularly to support mental well-being.
- Practice stress-reduction techniques like meditation or yoga.
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