Xadu
Generic Name
Xadufos
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xadu 70 mg tablet | ৳ 450.00 | N/A |
Description
Overview of the medicine
Xadu 70 mg Tablet is a bisphosphonate used for the treatment and prevention of osteoporosis in postmenopausal women and for increasing bone mass in men with osteoporosis. It helps to slow bone loss and may help rebuild bone, reducing the risk of fractures.
Uses & Indications
Dosage
Adults
For osteoporosis treatment: 70 mg once weekly. For osteoporosis prevention: 35 mg once weekly (if available).
Elderly
No dosage adjustment is generally required for elderly patients with normal renal function.
Renal_impairment
Not recommended for patients with creatinine clearance <35 mL/min. For patients with mild to moderate renal impairment, no dosage adjustment is needed, but caution is advised.
How to Take
Take the tablet with a full glass of plain water (not mineral water, coffee, juice, or milk) first thing in the morning, at least 30 minutes before any food, drink, or other medications. Remain upright (sitting or standing) for at least 30 minutes after taking the tablet and until after the first meal of the day to minimize esophageal irritation.
Mechanism of Action
Xadufos acts as a potent, non-hormonal antiresorptive agent. It preferentially localizes to sites of bone resorption, specifically under osteoclasts, and inhibits osteoclast activity, thereby reducing bone resorption without directly affecting bone mineralization.
Pharmacokinetics
Onset
Clinical effects on bone turnover may be observed within weeks; significant increase in BMD typically seen after 6-12 months.
Excretion
Approximately 50% of absorbed drug is excreted unchanged via the kidneys; the remainder is incorporated into bone.
Half life
Plasma half-life is very short (several hours), but the effective half-life in bone can be many years due to strong binding to bone mineral.
Absorption
Poorly absorbed from the GI tract (typically <1%), and absorption is significantly reduced by food and certain medications. Peak plasma concentration achieved within 1 hour.
Metabolism
Not metabolized in humans.
Side Effects
Contraindications
- Abnormalities of the esophagus which delay esophageal emptying (e.g., stricture or achalasia).
- Inability to stand or sit upright for at least 30 minutes.
- Hypocalcemia.
- Hypersensitivity to any component of the product.
Drug Interactions
Calcium supplements/Antacids
Significantly interfere with the absorption of Xadufos. Must be taken at least 30 minutes after Xadufos.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Concurrent use may increase the risk of upper gastrointestinal adverse events.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may result in hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer. Milk or antacids should be given to bind Xadufos. Patients should be observed for signs of hypocalcemia.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation due to lack of adequate data and potential for fetal harm. Women of childbearing potential should use effective contraception.
Side Effects
Contraindications
- Abnormalities of the esophagus which delay esophageal emptying (e.g., stricture or achalasia).
- Inability to stand or sit upright for at least 30 minutes.
- Hypocalcemia.
- Hypersensitivity to any component of the product.
Drug Interactions
Calcium supplements/Antacids
Significantly interfere with the absorption of Xadufos. Must be taken at least 30 minutes after Xadufos.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Concurrent use may increase the risk of upper gastrointestinal adverse events.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may result in hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer. Milk or antacids should be given to bind Xadufos. Patients should be observed for signs of hypocalcemia.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation due to lack of adequate data and potential for fetal harm. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved (Hypothetical DGDA approval)
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials have demonstrated Xadufos's efficacy in increasing bone mineral density and reducing the incidence of vertebral and hip fractures in postmenopausal women with osteoporosis. Ongoing studies explore its use in other bone conditions.
Lab Monitoring
- Serum calcium and vitamin D levels (before initiation and periodically)
- Renal function (creatinine clearance)
Doctor Notes
- Emphasize proper administration technique to patients to minimize esophageal adverse events.
- Assess calcium and vitamin D status before initiating therapy and ensure supplementation if needed.
- Consider a 'drug holiday' after 3-5 years of use for some patients, depending on fracture risk assessment.
Patient Guidelines
- Follow strict administration instructions (first thing in morning, plain water, upright position for 30 min).
- Ensure adequate calcium and vitamin D intake through diet or supplements.
- Report any new or unusual thigh, hip, or groin pain immediately.
Missed Dose Advice
If a dose is missed, take one tablet on the morning after remembering. Do not take two tablets on the same day. Return to taking one tablet once a week on your regularly scheduled day.
Driving Precautions
Xadu 70 mg Tablet is not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid driving.
Lifestyle Advice
- Regular weight-bearing exercise (e.g., walking) can help strengthen bones.
- Maintain a balanced diet rich in calcium and vitamin D.
- Avoid smoking and excessive alcohol consumption, as these can negatively impact bone health.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Xadu Brand
Other medicines available under the same brand name
