Xanuric
Generic Name
Flobicoxib
Manufacturer
PharmaGen Corp.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xanuric 120 mg tablet | ৳ 34.00 | ৳ 340.00 |
Description
Overview of the medicine
Xanuric 120 mg Tablet contains Flobicoxib, a selective COX-2 inhibitor, used for the symptomatic relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
Osteoarthritis: 60 mg once daily. Rheumatoid Arthritis: 90 mg once daily. Acute pain: 120 mg once daily for a maximum of 8 days. Acute gouty arthritis: 120 mg once daily for maximum 8 days.
Elderly
No dose adjustment generally required, but caution is advised due to increased risk of adverse effects in elderly patients.
Renal_impairment
Mild to moderate renal impairment: No dose adjustment needed. Severe renal impairment (CrCl <30 mL/min): Not recommended.
How to Take
Take orally, once daily. Can be taken with or without food. For acute pain, use for the shortest duration necessary.
Mechanism of Action
Flobicoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, inflammatory mediators. By inhibiting COX-2, it reduces pain, inflammation, and fever.
Pharmacokinetics
Onset
Onset of action typically occurs within 30-60 minutes.
Excretion
Excreted primarily via the urine (approximately 70%) and feces (approximately 30%), mainly as metabolites.
Half life
Elimination half-life is approximately 10-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, achieving peak plasma concentrations within 1-2 hours. Bioavailability is approximately 80-90%.
Metabolism
Primarily metabolized in the liver, mainly via cytochrome P450 (CYP) enzymes, particularly CYP3A4 and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to Flobicoxib or any component of the tablet
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic or renal impairment
- Congestive heart failure (NYHA Class II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Cyclosporine and Tacrolimus
Increased nephrotoxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the third trimester, due to potential fetal harm. Avoid during lactation as Flobicoxib may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Flobicoxib or any component of the tablet
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic or renal impairment
- Congestive heart failure (NYHA Class II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Cyclosporine and Tacrolimus
Increased nephrotoxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the third trimester, due to potential fetal harm. Avoid during lactation as Flobicoxib may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent protected
Clinical Trials
Extensive Phase III clinical trials demonstrated efficacy and safety in various pain and inflammatory conditions. Post-marketing surveillance is ongoing.
Lab Monitoring
- Regular monitoring of blood pressure, especially in patients with pre-existing hypertension.
- Monitoring of renal function (serum creatinine, BUN) periodically, especially in elderly patients or those with pre-existing renal impairment.
- Monitoring of liver function tests (ALT, AST) if signs of hepatic dysfunction appear.
Doctor Notes
- Assess cardiovascular risk factors before initiating therapy with Xanuric.
- Monitor blood pressure regularly, especially in patients with hypertension.
- Monitor renal function periodically, particularly in elderly patients or those with compromised renal function.
- Use the lowest effective dose for the shortest possible duration to minimize risks.
Patient Guidelines
- Take Xanuric exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual symptoms, especially gastrointestinal bleeding (e.g., black, tarry stools) or signs of cardiovascular events (e.g., chest pain, shortness of breath) immediately to your doctor.
- Do not combine with other NSAIDs or aspirin without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Xanuric may cause dizziness or drowsiness in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid or limit alcohol consumption as it may increase the risk of stomach problems.
- Maintain a healthy diet and regular exercise as advised by your healthcare provider.
- Quit smoking to reduce cardiovascular risks.
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