Xerocid
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xerocid 500 mg suspension | ৳ 125.00 | N/A |
| xerocid 500 mg chewable tablet | ৳ 3.50 | N/A |
Description
Overview of the medicine
Xerocid (Cefixime) is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, otitis media, and pharyngitis.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing over 50 kg: 400 mg once daily or 200 mg twice daily. For uncomplicated gonorrhea, a single dose of 400 mg.
Elderly
No specific dose adjustment necessary unless renal function is significantly impaired.
Renal_impairment
CrCl 21-60 mL/min: 300 mg daily. CrCl <20 mL/min or hemodialysis: 200 mg daily. Peritoneal dialysis: 200 mg daily.
How to Take
Can be taken with or without food. To minimize gastrointestinal upset, it is often recommended to take with food.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
Pharmacokinetics
Onset
Variable, generally within hours for antibacterial effect.
Excretion
Primarily renal (glomerular filtration and tubular secretion) with some biliary excretion.
Half life
3-4 hours
Absorption
Approximately 40-50% orally absorbed. Food slightly delays Tmax but does not significantly alter Cmax or AUC.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
Increased prothrombin time
Carbamazepine
Increased carbamazepine levels
Anticoagulants
Increased bleeding risk
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
Increased prothrombin time
Carbamazepine
Increased carbamazepine levels
Anticoagulants
Increased bleeding risk
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months, varies by specific formulation and manufacturer.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA/FDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Cefixime for various bacterial infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (for prolonged therapy)
- Liver function tests (rarely indicated)
Doctor Notes
- Consider patient history of beta-lactam allergy before prescribing.
- Monitor for signs of superinfection with prolonged use.
- Adjust dose in renal impairment.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally no known effects on ability to drive or operate machinery. If dizziness occurs, caution is advised.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment (though not directly interacting, good practice for infection).
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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