Xetril
Generic Name
Ropinirole 2 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xetril 2 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ropinirole is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease and moderate to severe primary restless legs syndrome (RLS). It helps to improve motor symptoms by stimulating dopamine receptors in the brain.
Uses & Indications
Dosage
Adults
Parkinson's Disease: Initial dose of 0.25 mg three times daily, titrated gradually based on response and tolerability, up to a maximum of 24 mg/day. Restless Legs Syndrome: Initial dose of 0.25 mg once daily, 1-3 hours before bedtime, titrated based on response and tolerability, up to a maximum of 4 mg/day.
Elderly
No specific dose adjustment is required, but doses should be titrated carefully, especially if there is decreased renal function.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment (CrCl 30-50 mL/min). For severe renal impairment (CrCl < 30 mL/min), dose reduction may be required. Not recommended for patients on hemodialysis.
How to Take
Xetril tablets should be taken orally, with or without food. For Parkinson's disease, it is usually taken three times a day. For Restless Legs Syndrome, it should be taken once daily, 1-3 hours before bedtime.
Mechanism of Action
Ropinirole selectively stimulates postsynaptic D2 and D3 dopamine receptors in the brain. Its exact mechanism of action in Parkinson's disease and RLS is believed to be related to its ability to mimic dopamine, thereby restoring dopaminergic neurotransmission.
Pharmacokinetics
Onset
For Parkinson's disease, therapeutic effects are seen gradually over several weeks. For RLS, symptom improvement can begin within days.
Excretion
Approximately 88% of the dose is excreted in the urine as metabolites, with less than 10% excreted as unchanged drug.
Half life
The elimination half-life is approximately 6 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. Absolute bioavailability is approximately 50%.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 CYP1A2 isoenzyme, to inactive metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to ropinirole or any excipients of the formulation.
- •Severe hepatic impairment (use with caution).
Drug Interactions
Levodopa
May increase the incidence of dyskinesia when co-administered in advanced Parkinson's disease.
Estrogens (e.g., hormone replacement therapy)
May decrease ropinirole clearance, potentially leading to increased levels.
CYP1A2 Inhibitors (e.g., Ciprofloxacin, Fluvoxamine)
May increase ropinirole plasma levels, requiring dose reduction.
Dopamine Antagonists (e.g., antipsychotics, metoclopramide)
May reduce the efficacy of ropinirole.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, somnolence, hyperkinesia, and occasionally abdominal pain. Management is supportive, including gastric lavage and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Ropinirole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may inhibit lactation; therefore, breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
FDA approved, DGDA approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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