Ximeclav
Generic Name
Cefixime Trihydrate + Clavulanic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ximeclav 250 mg tablet | ৳ 34.50 | ৳ 345.00 |
| ximeclav 500 mg tablet | ৳ 57.50 | ৳ 345.00 |
| ximeclav 125 mg suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Ximeclav is an antibiotic combination containing Cefixime, a third-generation cephalosporin, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Cefixime 200 mg + Clavulanic Acid 125 mg, twice daily for 5-10 days, depending on the severity of infection.
Elderly
No specific dose adjustment is required for elderly patients unless there is significant renal impairment.
Renal_impairment
Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
To be taken orally, with or without food. For best absorption and to reduce gastrointestinal upset, it is advisable to take with food.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that protects Cefixime from degradation by beta-lactamase enzymes produced by resistant bacteria, thereby extending its antibacterial spectrum.
Pharmacokinetics
Onset
Rapid absorption with peak plasma concentrations occurring within 2-6 hours for Cefixime and 1-2 hours for Clavulanic Acid.
Excretion
Cefixime is primarily excreted renally via glomerular filtration and tubular secretion. Clavulanic acid is excreted renally and non-renally.
Half life
Cefixime: approximately 3-4 hours. Clavulanic Acid: approximately 1 hour.
Absorption
Cefixime is 40-50% absorbed orally. Clavulanic acid is well absorbed orally.
Metabolism
Cefixime undergoes limited hepatic metabolism. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- Hypersensitivity to Clavulanic Acid or other beta-lactam antibiotics
- History of cholestatic jaundice or hepatic dysfunction associated with penicillin or cephalosporin use
Drug Interactions
Warfarin
May increase anticoagulant effect and risk of bleeding; monitor INR closely.
Probenecid
May increase Cefixime plasma concentrations and prolong its half-life.
Oral Contraceptives
May decrease the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Reconstituted dry syrup should be stored in a refrigerator (2-8°C) and used within 7-14 days.
Overdose
In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment is recommended. Hemodialysis is not likely to be beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy and lactation, only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- Hypersensitivity to Clavulanic Acid or other beta-lactam antibiotics
- History of cholestatic jaundice or hepatic dysfunction associated with penicillin or cephalosporin use
Drug Interactions
Warfarin
May increase anticoagulant effect and risk of bleeding; monitor INR closely.
Probenecid
May increase Cefixime plasma concentrations and prolong its half-life.
Oral Contraceptives
May decrease the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Reconstituted dry syrup should be stored in a refrigerator (2-8°C) and used within 7-14 days.
Overdose
In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment is recommended. Hemodialysis is not likely to be beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy and lactation, only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Refer to the product packaging for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Cefixime and Clavulanic Acid individually and in combination. Post-marketing surveillance continues to monitor real-world outcomes.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Liver function tests (rarely, in case of liver dysfunction symptoms)
- Complete blood count (in prolonged or high-dose therapy)
Doctor Notes
- Before prescribing, consider performing bacterial culture and susceptibility testing if appropriate, especially in recurrent or severe infections.
- Advise patients about the potential for antibiotic-associated diarrhea and to seek medical attention if severe or persistent.
- Adjust dosage in patients with significant renal impairment.
Patient Guidelines
- Take the full course of medication as prescribed, even if you feel better, to prevent recurrence and resistance.
- Do not stop taking the medicine without consulting your doctor.
- Do not share this medication with others, as it may not be suitable for their condition.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe for driving and operating machinery. However, if dizziness or other adverse effects that impair concentration occur, avoid these activities.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of infections.
- Ensure adequate fluid intake to help flush out toxins and support kidney function.
- Avoid self-medication for future infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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