Medicine Information

Ximeclav

Name: Ximeclav
Brand: Ximeclav
Rating: 4.5 (117 reviews)

TabletCefuroxime 250 mg & Clavulanic Acid 62.5 mgAntibiotics (Beta-Lactam Antibiotics with Beta-Lactamase Inhibitor)ATC: J01RA02

Generic Name

Cefuroxime (as Axetil) + Clavulanic Acid (as Potassium Clavulanate)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ximeclav 250 mg tablet	৳ 34.50	৳ 345.00

Description

Overview of the medicine

Ximeclav 250 mg Tablet is a combination antibiotic containing Cefuroxime axetil and Clavulanic acid. It is used to treat a wide range of bacterial infections susceptible to this combination, including respiratory tract infections, urinary tract infections, and skin and soft tissue infections.

Uses & Indications

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia, sinusitis, pharyngitis, tonsillitis)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., cellulitis, erysipelas, wound infections)

Otitis media

Gonorrhoea

Dosage

Adults

One 250 mg/62.5 mg tablet twice daily for 5-10 days, depending on the severity and type of infection. For more severe infections, a higher strength (e.g., 500 mg/125 mg) may be indicated.

Elderly

No specific dose adjustment is required in elderly patients with normal renal function. Dosage should be adjusted based on renal function if impaired.

Renal_impairment

Dosage adjustment is necessary in patients with significant renal impairment. Consult product leaflet for specific creatinine clearance guidelines.

How to Take

Take orally, preferably with food, as food enhances the absorption of cefuroxime axetil. Swallow the tablet whole; do not chew or crush.

Mechanism of Action

Cefuroxime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that prevents the breakdown of cefuroxime by beta-lactamase enzymes produced by some bacteria, thereby extending its antibacterial spectrum.

Pharmacokinetics

Onset

Rapid, with peak plasma concentrations typically achieved within 1-2 hours after oral administration.

Excretion

Both cefuroxime and clavulanic acid are primarily excreted by the kidneys, with cefuroxime being excreted unchanged via glomerular filtration and tubular secretion, and clavulanic acid as metabolites and unchanged drug.

Half life

Cefuroxime: approximately 1.2-1.5 hours. Clavulanic Acid: approximately 1 hour.

Absorption

Cefuroxime axetil is well absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime. Clavulanic acid is also well absorbed. Absorption is enhanced when taken with food.

Metabolism

Cefuroxime is not extensively metabolized. Clavulanic acid is extensively metabolized to inactive compounds.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, clavulanic acid, or any other cephalosporin antibiotics.
History of severe hypersensitivity (e.g., anaphylaxis) to any other beta-lactam antibiotic (e.g., penicillins).
History of cholestatic jaundice/hepatic dysfunction associated with penicillin or cefuroxime/clavulanic acid therapy.

Drug Interactions

Probenecid

Concomitant use with probenecid increases cefuroxime plasma concentrations and prolongs its half-life by reducing renal tubular secretion.

Oral Anticoagulants

May prolong prothrombin time (INR) in patients receiving oral anticoagulants. Close monitoring is advised.

Oral Contraceptives

May reduce the efficacy of oral contraceptives; additional non-hormonal contraception may be advisable.

Antacids/H2 blockers

May decrease the bioavailability of cefuroxime axetil; administer at least 1-2 hours apart.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and convulsions. Management is supportive, and hemodialysis may be considered to remove the drug from circulation.

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy and lactation only if clearly needed and under strict medical supervision. Small amounts of cefuroxime and clavulanic acid are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 6 tablets (blister pack)1 x 10 tablets (blister pack)

Shelf Life

Typically 24 to 36 months from the date of manufacture, specific details on packaging.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety profile of cefuroxime/clavulanic acid combination in various bacterial infections.

Lab Monitoring

Monitor renal function (creatinine clearance) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
Monitor liver function tests periodically, especially in patients with hepatic dysfunction or during prolonged treatment.
Monitor INR in patients on oral anticoagulants.

Doctor Notes

Emphasize the importance of completing the full antibiotic course to patients.
Monitor for signs of Clostridioides difficile-associated diarrhea (CDAD), especially in patients with prolonged or severe diarrhea.
Assess renal function, particularly in elderly patients or those with pre-existing renal impairment, and adjust dosage accordingly.

Patient Guidelines

Complete the full course of antibiotics as prescribed by your doctor, even if you feel better.
Take the medicine with food to enhance absorption and reduce stomach upset.
Do not share your medicine with others, and do not save it for future infections.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness. If you experience dizziness, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Maintain adequate hydration by drinking plenty of fluids.
Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.
Practice good hygiene to prevent the spread of infection.