Zosert
Generic Name
Sertraline
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zosert 25 mg tablet | ৳ 3.01 | ৳ 30.10 |
| zosert 50 mg tablet | ৳ 7.00 | ৳ 70.00 |
| zosert 100 mg tablet | ৳ 10.03 | ৳ 100.30 |
Description
Overview of the medicine
Zosert (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose 25-50 mg once daily; may be increased gradually up to a maximum of 200 mg once daily, depending on indication and patient response.
Elderly
Lower starting doses and slower titration may be considered; maximum dose of 200 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Administer orally once daily, in the morning or evening. Can be taken with or without food.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron in the central nervous system, thereby increasing the concentration of serotonin in the synaptic cleft.
Pharmacokinetics
Onset
Initial effects may be observed within 1-2 weeks, but full therapeutic effect usually takes 2-4 weeks.
Excretion
Excreted primarily in feces (40-45%) and urine (13-16%) as metabolites.
Half life
Approximately 26 hours (range 22-36 hours).
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached in 4.5-8.4 hours. Food enhances absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, to N-desmethylsertraline, an active but less potent metabolite.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment
- Hypersensitivity to sertraline or any component of the formulation
- Concomitant use with pimozide
Drug Interactions
MAOIs
Increased risk of serotonin syndrome, may be fatal.
Pimozide
Increased pimozide levels, QT prolongation.
Warfarin
May increase prothrombin time and bleeding risk.
Other serotonergic drugs (e.g., other SSRIs, SNRIs, triptans, fentanyl, tramadol)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures and coma. Treatment is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; consult a doctor before breastfeeding.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment
- Hypersensitivity to sertraline or any component of the formulation
- Concomitant use with pimozide
Drug Interactions
MAOIs
Increased risk of serotonin syndrome, may be fatal.
Pimozide
Increased pimozide levels, QT prolongation.
Warfarin
May increase prothrombin time and bleeding risk.
Other serotonergic drugs (e.g., other SSRIs, SNRIs, triptans, fentanyl, tramadol)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures and coma. Treatment is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; consult a doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA/DGDA approved
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Numerous placebo-controlled and active-comparator clinical trials have demonstrated the efficacy and safety of sertraline for its approved indications, including MDD, OCD, panic disorder, PTSD, PMDD, and social anxiety disorder.
Lab Monitoring
- Monitor liver function tests periodically, especially in patients with hepatic impairment
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to risk of hyponatremia
Doctor Notes
- Counsel patients on the delayed onset of therapeutic action and the importance of continued treatment.
- Monitor closely for suicidal ideation, especially during initiation and dose adjustments, in young patients.
- Advise patients on potential drug interactions, especially with MAOIs and other serotonergic agents.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can lead to withdrawal symptoms.
- Report any new or worsening symptoms of depression, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
- It may take several weeks to feel the full benefits of this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Sertraline may cause dizziness, drowsiness, or blurred vision. Do not drive or operate heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while on sertraline.
- Engage in regular physical activity and maintain a balanced diet.
- Practice good sleep hygiene and stress management techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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