Medicine Information

AcmeCilin

Name: AcmeCilin
Brand: AcmeCilin
Rating: 4.5 (117 reviews)

Capsule250 mgAntibiotics, PenicillinsATC: J01CA04

Generic Name

Amoxicillin

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
acmecilin 250 mg capsule	৳ 3.34	৳ 33.40

Description

Overview of the medicine

AcmeCilin 250 mg Capsule contains Amoxicillin, a penicillin-type antibiotic used to treat a wide range of bacterial infections.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections

Otitis media

Pharyngitis/Tonsillitis

H. pylori eradication (in combination therapy)

Dosage

Adults

250 mg to 500 mg every 8 hours, or 500 mg to 875 mg every 12 hours, depending on infection severity and type.

Elderly

Similar to adult dosage, but dose reduction may be required in severe renal impairment.

Renal_impairment

Dose adjustment required based on creatinine clearance. For CrCl <30 mL/min, dosage intervals may be extended or dose reduced.

How to Take

Oral. Can be taken with or without food. Swallow capsule whole with water.

Mechanism of Action

Amoxicillin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Pharmacokinetics

Onset

Within 1 hour

Excretion

Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, not significantly affected by food.

Metabolism

Minimally metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to amoxicillin, penicillin, or any component of the formulation
History of severe allergic reaction to other beta-lactam antibiotics

Drug Interactions

Warfarin

May enhance anticoagulant effect, increasing risk of bleeding.

Allopurinol

Increased risk of skin rash.

Methotrexate

May increase methotrexate toxicity due to reduced renal clearance.

Oral contraceptives

May reduce efficacy of oral contraceptives (rare).

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include nausea, vomiting, diarrhea, abdominal pain, and rarely convulsions. Treatment is largely supportive; hemodialysis can aid removal.

Pregnancy & Lactation

Generally considered safe in pregnancy (Category B). Excreted in breast milk in small amounts; generally considered safe during lactation, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules100 capsules (institutional pack)

Shelf Life

24 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA/FDA

Patent Status

Generic, Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for decades. Specific trials for AcmeCilin brand not typically required for generics.

Lab Monitoring

Renal function (in prolonged therapy or renal impairment)
Liver function tests (rarely needed)
CBC (in prolonged therapy)

Doctor Notes

Prescribe appropriate dosage and duration based on infection severity and patient's renal function.
Advise patients on the importance of completing the full course.
Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.

Patient Guidelines

Complete the full course of medication even if symptoms improve.
Do not share this medicine with others.
Contact your doctor if symptoms worsen or do not improve.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

Take the missed dose as soon as you remember. If it's close to the next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose.