Acmecilin 250 mg Injection can be administered either intramuscularly (IM) or intravenously (IV). For IV administration, the powder should be reconstituted with sterile water for injection and then diluted further before slow intravenous infusion. For IM administration, reconstitute and inject deep into a large muscle.

Ampicillin exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and bacterial death.

• •Hypersensitivity to ampicillin, any other penicillin, or any component of the formulation.
• •History of severe allergic reaction to any beta-lactam antibiotic (e.g., anaphylaxis).
• •Infectious mononucleosis (may cause a non-allergic rash).

Store below 30°C in a dry place, away from light. Reconstituted solutions should be used immediately or stored as per specific manufacturer instructions, typically for a short period under refrigeration.

Symptoms of overdose may include severe gastrointestinal disturbances (nausea, vomiting, diarrhea), neurological symptoms (convulsions, especially in patients with impaired renal function or high doses). Treatment is supportive and symptomatic; hemodialysis may be effective in removing ampicillin from the bloodstream.

Pregnancy Category B. Ampicillin is generally considered safe during pregnancy when clearly needed. It is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing mother. Consult a healthcare professional.