Adults

One 875 mg/125 mg tablet twice daily (every 12 hours) for 7 to 10 days, depending on the severity and type of infection.

Elderly

No specific dosage adjustment is generally required unless there is severe renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance 10-30 mL/min, 875 mg/125 mg every 24 hours. For creatinine clearance less than 10 mL/min, 500 mg/125 mg every 24 hours. Hemodialysis patients should receive 500 mg/125 mg every 24 hours, with an additional dose during and at the end of dialysis.

Onset

Peak plasma concentrations are achieved approximately 1-2 hours post-administration.

Excretion

Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.

Half life

Amoxicillin: approximately 1-1.3 hours; Clavulanic acid: approximately 1 hour.

Absorption

Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration, with clavulanic acid enhancing the absorption of amoxicillin.

Metabolism

Amoxicillin is largely excreted unchanged; clavulanic acid is extensively metabolized to inactive compounds.

Probenecid

Concomitant use with probenecid may decrease the renal tubular secretion of amoxicillin, resulting in increased and prolonged blood levels of amoxicillin.

Allopurinol

Concomitant administration with allopurinol may increase the incidence of skin rashes, particularly in patients with hyperuricemia.

Methotrexate

Amoxicillin may reduce the renal excretion of methotrexate, potentially increasing methotrexate toxicity.

Oral Contraceptives

May reduce the efficacy of oral contraceptives; advise use of additional non-hormonal contraception.

Oral Anticoagulants (e.g., Warfarin)

May prolong prothrombin time. Close monitoring of coagulation parameters is recommended.