Amoxon
Generic Name
Amoxicillin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amoxon 250 mg capsule | ৳ 3.62 | ৳ 36.20 |
Description
Overview of the medicine
Amoxon 250 mg Capsule contains Amoxicillin, a broad-spectrum penicillin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typical adult dose: 250 mg to 500 mg every 8 hours, or 500 mg to 875 mg every 12 hours, depending on the infection severity and type.
Elderly
Dosage adjustments may be necessary based on renal function.
Renal_impairment
Dose reduction or increased dosing interval may be required; e.g., for CrCl < 30 mL/min, dosage adjustment is necessary.
How to Take
Oral administration. Can be taken with or without food. For best absorption, it is often recommended to take it at the start of a meal.
Mechanism of Action
Amoxicillin acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted unchanged by the kidneys via tubular secretion and glomerular filtration. Approximately 60-80% of a dose is excreted in urine within 6 hours.
Half life
Approximately 1-1.5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, especially when taken with or without food. Bioavailability is approximately 70-90%.
Metabolism
Limited metabolism, primarily to inactive penicilloic acid.
Side Effects
Contraindications
- Hypersensitivity to amoxicillin or any other penicillin antibiotic
- History of severe allergic reaction to beta-lactam antibiotics (e.g., cephalosporins, carbapenems)
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but caution advised).
Warfarin and other oral anticoagulants
May increase the anticoagulant effect, requiring monitoring of INR.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea) and disturbances of fluid and electrolyte balance. In rare cases, crystalluria or renal impairment may occur. Treatment is generally supportive and symptomatic. Hemodialysis may be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy, but use only if clearly needed. Excreted in breast milk in small amounts; generally considered safe for breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- Hypersensitivity to amoxicillin or any other penicillin antibiotic
- History of severe allergic reaction to beta-lactam antibiotics (e.g., cephalosporins, carbapenems)
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but caution advised).
Warfarin and other oral anticoagulants
May increase the anticoagulant effect, requiring monitoring of INR.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea) and disturbances of fluid and electrolyte balance. In rare cases, crystalluria or renal impairment may occur. Treatment is generally supportive and symptomatic. Hemodialysis may be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy, but use only if clearly needed. Excreted in breast milk in small amounts; generally considered safe for breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic (patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of amoxicillin for various bacterial infections since its introduction. Ongoing research focuses on resistance patterns and new formulations.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with impaired renal function)
- Liver function tests (rarely, in patients with pre-existing liver disease or prolonged use)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Confirm penicillin allergy history before prescribing.
- Advise patient to complete the full course.
- Monitor for signs of superinfection.
- Consider renal function in elderly or impaired patients for dose adjustment.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if symptoms do not improve or worsen.
- Report any severe allergic reactions immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Amoxicillin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could affect concentration, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Follow your doctor's advice regarding diet and rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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