Amoxon
Generic Name
Amoxicillin
Manufacturer
Local Manufacturer Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amoxon 500 mg capsule | ৳ 6.78 | ৳ 33.90 |
Description
Overview of the medicine
Amoxicillin is a penicillin-type antibiotic used to treat various bacterial infections, including those of the respiratory tract, urinary tract, skin, and ear.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours or 500-875 mg every 12 hours, depending on the severity and type of infection. Max 4.5 g/day.
Elderly
Similar to adults, but dose adjustment may be necessary in case of impaired renal function.
Renal_impairment
Dose reduction or extended dosing interval required based on creatinine clearance (e.g., 250-500 mg every 12-24 hours for severe impairment).
How to Take
Take orally with or without food. Swallow the capsule whole with water. Complete the full course of treatment even if symptoms improve.
Mechanism of Action
Amoxicillin works by inhibiting the synthesis of the bacterial cell wall, leading to bacterial cell death.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Primarily renal (urine) as unchanged drug (50-70% of dose) within 6-8 hours.
Half life
About 1-1.5 hours in individuals with normal renal function.
Absorption
Rapidly and well absorbed after oral administration, with good bioavailability.
Metabolism
Limited; approximately 10-25% of the dose is metabolized, primarily by hydrolysis of the beta-lactam ring.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin, any other penicillin, or to any of the excipients.
- History of severe immediate hypersensitivity reaction (e.g., anaphylaxis) to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam).
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR closely.
Allopurinol
Increased incidence of skin rashes, especially in patients with hyperuricemia.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (rarely).
Storage
Store in a cool, dry place below 30°C. Protect from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal symptoms (nausea, vomiting, diarrhea) and disturbances in fluid and electrolyte balance. Management is supportive, including gastric lavage or induced emesis if ingestion is recent. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation. Consult a doctor before use.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin, any other penicillin, or to any of the excipients.
- History of severe immediate hypersensitivity reaction (e.g., anaphylaxis) to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam).
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR closely.
Allopurinol
Increased incidence of skin rashes, especially in patients with hyperuricemia.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (rarely).
Storage
Store in a cool, dry place below 30°C. Protect from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal symptoms (nausea, vomiting, diarrhea) and disturbances in fluid and electrolyte balance. Management is supportive, including gastric lavage or induced emesis if ingestion is recent. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to manufacturer's instructions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Amoxicillin has been extensively studied in numerous clinical trials establishing its efficacy and safety for a wide range of bacterial infections over decades. Post-marketing surveillance continues to monitor its safety profile.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete Blood Count (CBC) (for prolonged therapy)
- Liver function tests (if hepatic dysfunction is suspected)
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance.
- Advise patients to report any signs of allergic reaction immediately.
- Consider renal function in elderly or renally impaired patients for dose adjustments.
- Educate on potential for C. difficile infection (CDI) with prolonged use.
Patient Guidelines
- Take the full course of medicine as prescribed, even if you feel better.
- Do not share your medicine with others.
- Inform your doctor about any unusual side effects or allergic reactions.
- Discard any unused medicine safely.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Amoxicillin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects, avoid these activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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