Adults

Not typically administered as pediatric drops to adults; adult dosages vary by indication (e.g., 50-400 mg daily).

Elderly

Dosage may need adjustment based on renal function; refer to adult guidelines.

Children

Dosage is highly dependent on indication and weight. For Oropharyngeal candidiasis: 6 mg/kg on day 1, then 3 mg/kg once daily. For Systemic candidiasis: 6-12 mg/kg once daily.

Renal_impairment

Dosage reduction is necessary for patients with impaired renal function (creatinine clearance < 50 mL/min). Typically, an initial loading dose is given, followed by 50% of the usual daily dose.

Onset

Within 24-48 hours for symptomatic improvement.

Excretion

Primarily excreted unchanged in the urine (approximately 80% of the dose).

Half life

Approximately 20-30 hours (children may have shorter half-life).

Absorption

Well absorbed orally; bioavailability is >90% of IV dose. Peak plasma concentrations typically occur within 1-2 hours post-administration.

Metabolism

Minimally metabolized; approximately 11% of the drug is metabolized in the liver.

Warfarin

Increased prothrombin time; monitor INR closely.

Phenytoin

Increased phenytoin levels; monitor levels and adjust dose.

Rifampicin

Decreased fluconazole levels; consider increasing fluconazole dose.

Cyclosporine, Tacrolimus

Increased levels of immunosuppressants; monitor levels.