Adults

Generally not applicable for typical adult dosing, primarily used in pediatric patients. For specific adult indications, follow physician's advice.

Elderly

No specific dose adjustment is generally required unless severe renal or hepatic impairment is present.

Children

For otitis media and respiratory tract infections: 10 mg/kg orally once daily for 3 days, or 10 mg/kg on Day 1 followed by 5 mg/kg on Days 2-5.

Renal_impairment

No dose adjustment for mild to moderate renal impairment; caution advised in severe impairment.

Onset

Therapeutic effects typically begin within 2-3 hours.

Excretion

Mainly excreted unchanged via the biliary route, with a small portion excreted renally.

Half life

Plasma elimination half-life is approximately 68-72 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.

Metabolism

Undergoes minor hepatic metabolism, primarily via CYP3A4.

Warfarin

May increase the anticoagulant effect, leading to an elevated INR (International Normalized Ratio).

Nelfinavir

Coadministration may result in increased serum concentrations of Antif.

Cyclosporine

Antif may increase cyclosporine levels; monitor cyclosporine concentrations if coadministered.

Antacids (containing aluminum or magnesium)

Can decrease the absorption of Antif; administer Antif at least 2 hours before or 4 hours after antacids.