Medicine Information

Axim

Name: Axim
Brand: Axim

Tablet500 mgAntibioticATC: J01DC02

Generic Name

Cefuroxime Axetil

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
axim 500 mg tablet	৳ 45.00	৳ 450.00

Description

Overview of the medicine

Axim 500 mg Tablet contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media.

Uses & Indications

Pharyngitis/Tonsillitis

Acute Bacterial Otitis Media

Acute Bacterial Maxillary Sinusitis

Acute Bacterial Exacerbations of Chronic Bronchitis

Community-acquired Pneumonia

Uncomplicated Skin and Skin-structure Infections

Uncomplicated Urinary Tract Infections

Gonorrhea (uncomplicated urethral and endocervical)

Dosage

Adults

Most infections: 250 mg twice daily for 7-10 days. More severe infections (e.g., bronchitis, pneumonia): 500 mg twice daily for 7-10 days. Uncomplicated UTI: 250 mg twice daily for 3-7 days. Gonorrhea: 1000 mg as a single dose.

Elderly

Dosage similar to adults, but adjust for renal function.

Renal_impairment

Reduce dosage interval based on creatinine clearance. For CrCl 10-29 mL/min, administer standard dose every 24 hours. For CrCl <10 mL/min, administer standard dose every 48 hours.

How to Take

Oral. For optimal absorption, Axim 500 mg tablet should be taken with food. Do not crush or chew the tablet; swallow whole.

Mechanism of Action

Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, thereby disrupting the formation of peptidoglycan, an essential component of the bacterial cell wall. This leads to cell lysis and bacterial death.

Pharmacokinetics

Onset

Typically within 1 hour.

Excretion

Mainly excreted unchanged in the urine by glomerular filtration and tubular secretion.

Half life

Approximately 1.2 to 1.5 hours in adults.

Absorption

Well absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime. Enhanced absorption with food.

Metabolism

Not significantly metabolized; mainly hydrolyzed to cefuroxime in the intestinal mucosa and blood.

Side Effects

Contraindications

Known hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or to any of the excipients.
History of severe hypersensitivity to any other type of beta-lactam antibacterial agent (e.g., penicillins).

Drug Interactions

Probenecid

Increases cefuroxime levels by decreasing renal tubular secretion, potentially increasing toxicity.

Oral Contraceptives

May decrease efficacy of oral contraceptives. Advise using additional birth control.

Antacids/H2 Blockers/PPIs

May reduce bioavailability of cefuroxime axetil, especially if taken together. Separate administration times.

Aminoglycosides/Potent Diuretics

Concurrent use with cefuroxime may increase nephrotoxicity, monitor renal function.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include convulsions and other neurological disorders. Management involves symptomatic and supportive care. Hemodialysis and peritoneal dialysis can effectively remove cefuroxime from the body.

Pregnancy & Lactation

Pregnancy category B. Studies in animals have not shown harm to the fetus, but no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers. Monitor infants for diarrhea or candidiasis.

Side Effects

Contraindications

Known hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or to any of the excipients.
History of severe hypersensitivity to any other type of beta-lactam antibacterial agent (e.g., penicillins).

Drug Interactions

Probenecid

Increases cefuroxime levels by decreasing renal tubular secretion, potentially increasing toxicity.

Oral Contraceptives

May decrease efficacy of oral contraceptives. Advise using additional birth control.

Antacids/H2 Blockers/PPIs

May reduce bioavailability of cefuroxime axetil, especially if taken together. Separate administration times.

Aminoglycosides/Potent Diuretics

Concurrent use with cefuroxime may increase nephrotoxicity, monitor renal function.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

6 tablets/strip10 tablets/strip60 tablets/box

Shelf Life

Typically 24-36 months from the manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by FDA (USA), DGDA (Bangladesh)

Patent Status

Generic available (original patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of cefuroxime axetil for its approved indications. Ongoing post-marketing surveillance and studies continue to monitor its profile.

Lab Monitoring

Renal function tests (for prolonged therapy or in patients with impaired renal function)
Liver function tests (periodically if treatment is prolonged)
CBC (complete blood count)

Doctor Notes

Educate patients on the importance of completing the full course of antibiotics.
Advise patients to report any signs of allergic reaction or severe diarrhea immediately.
Consider renal function adjustment in elderly or renally impaired patients.

Patient Guidelines

Take the full course of medicine even if you feel better.
Take with food for better absorption and to reduce stomach upset.
Do not skip doses or stop taking the medicine early.
Inform your doctor if you experience severe diarrhea, rash, or breathing difficulties.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.