Medicine Information

Axim

Name: Axim
Brand: Axim
Rating: 4.5 (117 reviews)

Tablet125 mgAntibiotics (2nd generation Cephalosporins)ATC: J01DC02

Generic Name

Cefuroxime Axetil

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
axim 125 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Axim 125 mg Tablet contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.

Uses & Indications

Upper and lower respiratory tract infections (e.g., tonsillitis, pharyngitis, sinusitis, bronchitis, pneumonia)

Urinary tract infections (e.g., pyelonephritis, cystitis, urethritis)

Skin and soft tissue infections (e.g., furunculosis, pyoderma, impetigo)

Gonorrhea (uncomplicated, acute gonococcal urethritis and cervicitis)

Early Lyme disease

Dosage

Adults

Typical dose for mild to moderate infections is 250 mg twice daily. For 125 mg, often used for children or specific less severe adult infections, dosage must be prescribed by a physician. For pharyngitis/tonsillitis: 125 mg twice daily for 5-10 days.

Elderly

No special dosage adjustment is required unless there is severe renal impairment. Follow adult dosage.

Renal_impairment

Dosage should be adjusted based on creatinine clearance (CrCl). For CrCl 10-29 mL/min, 125-250 mg once daily. For CrCl <10 mL/min, 125-250 mg every 48 hours.

How to Take

Take the tablet orally with food for better absorption and to reduce gastrointestinal upset. Swallow whole, do not crush or chew.

Mechanism of Action

Cefuroxime Axetil is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) which interferes with the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved 2-3 hours after oral administration.

Excretion

Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.

Half life

Approximately 1-1.5 hours.

Absorption

Approximately 37-52% absorbed from the gastrointestinal tract, increased when taken with food.

Metabolism

Hydrolyzed by esterases in the intestinal mucosa and blood to release active cefuroxime. Not extensively metabolized in the liver.

Side Effects

Contraindications

Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
History of severe hypersensitivity reaction to any other beta-lactam antibiotics (e.g., penicillins).

Drug Interactions

Probenecid

Increases plasma concentration and prolongs the half-life of cefuroxime.

Oral Contraceptives

May reduce the efficacy of oral contraceptives. Additional non-hormonal contraception is recommended.

Antacids/H2-blockers/PPIs

May decrease the bioavailability of cefuroxime axetil by reducing gastric acidity. Cefuroxime axetil should be taken at least 2 hours before or several hours after these agents.

Storage

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include convulsions and other neurological disorders. Management is supportive, and hemodialysis may be effective in reducing serum cefuroxime levels.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets2 x 10 tablets

Shelf Life

2-3 years from manufacturing date

Availability

Available in pharmacies nationwide

Approval Status

Approved by regulatory bodies (e.g., DGDA)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Cefuroxime has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections.

Lab Monitoring

Liver function tests (ALT, AST) if long-term use or underlying liver disease.
Renal function tests (Creatinine, BUN) in patients with renal impairment or during prolonged high-dose therapy.
Complete blood count (CBC) occasionally, especially if treatment is prolonged.

Doctor Notes

Consider cross-sensitivity in patients with penicillin allergy history.
Monitor renal function in elderly patients and those with pre-existing renal impairment.
Advise patients to report any severe diarrhea, as it could indicate Clostridium difficile infection.

Patient Guidelines

Complete the full course of medication as prescribed by your doctor, even if your symptoms improve.
Take this medicine with food to enhance absorption and reduce stomach upset.
Inform your doctor if you develop severe or persistent diarrhea during or after treatment.
Do not share your medicine with others.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

This medicine may cause dizziness. If you experience dizziness, avoid driving or operating heavy machinery.

Lifestyle Advice

Maintain good hydration by drinking plenty of fluids.
Avoid alcohol consumption during antibiotic treatment, as it may exacerbate side effects.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Cefox 125mg Tablet (Incepta)Furox 125mg Tablet (Beximco)Acrox 125mg Tablet (Acme)Cefotil 125mg Tablet (Renata)

Global Brand Names

International brand names for this medicine

Acme Laboratories Ltd.

TabletParacetamol 500 mg + Caffeine 65 mg

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