Axodin
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| axodin 120 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Axodin 120 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis: 120 mg once daily. For chronic idiopathic urticaria: 180 mg once daily.
Elderly
No dosage adjustment is generally recommended for elderly patients unless they have impaired renal function.
Renal_impairment
For adults with impaired renal function, the recommended starting dose is 60 mg once daily.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juices.
Mechanism of Action
Fexofenadine is a selective peripheral H1-blocker. It inhibits the histamine H1 receptor, thereby blocking the effects of histamine and alleviating allergic symptoms like sneezing, runny nose, itchy eyes, and skin rashes.
Pharmacokinetics
Onset
Onset of action within 1 hour.
Excretion
Primarily excreted unchanged in the feces (80%), with a smaller portion (11%) in the urine.
Half life
Approximately 11-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached in 1-3 hours.
Metabolism
Minimally metabolized in the liver (about 5% metabolised).
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any components of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
Concomitant administration with these drugs may increase plasma levels of fexofenadine, though typically without clinically significant adverse effects.
Aluminum and magnesium-containing antacids
These antacids can reduce the absorption of fexofenadine. It is recommended to separate administration by about 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment is symptomatic and supportive; hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known if fexofenadine is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any components of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
Concomitant administration with these drugs may increase plasma levels of fexofenadine, though typically without clinically significant adverse effects.
Aluminum and magnesium-containing antacids
These antacids can reduce the absorption of fexofenadine. It is recommended to separate administration by about 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment is symptomatic and supportive; hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known if fexofenadine is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Patent expired for generic formulation
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic urticaria. Trials have shown it to be effective with a low incidence of central nervous system side effects.
Lab Monitoring
- No specific laboratory monitoring is routinely required.
Doctor Notes
- Consider dose adjustment for patients with renal impairment.
- Advise patients to avoid concurrent intake of fruit juices.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid consuming fruit juices (grapefruit, orange, apple) close to the time of taking this medicine.
- Inform your doctor or pharmacist about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Although fexofenadine is non-sedating, some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hydration.
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