Axodin
Generic Name
Fexofenadine Hydrochloride
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| axodin 60 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Fexofenadine is a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis and chronic idiopathic urticaria: 60 mg twice daily. Alternatively, 180 mg once daily.
Elderly
No specific dosage adjustment is generally recommended for elderly patients with normal renal function. Use with caution in elderly patients with impaired renal function.
Renal_impairment
For patients with impaired renal function (creatinine clearance < 80 mL/min), the recommended initial dose is 60 mg once daily.
How to Take
Take Axodin 60 mg tablet orally with water, preferably before a meal. Do not take with fruit juices (e.g., grapefruit, orange, apple) as they may reduce bioavailability.
Mechanism of Action
Fexofenadine selectively antagonizes peripheral H1-histamine receptors, thereby inhibiting the effects of histamine and alleviating allergic symptoms without significant central nervous system effects.
Pharmacokinetics
Onset
Onset of action typically occurs within 1 hour.
Excretion
Primarily excreted in the feces (approximately 80%) and urine (approximately 11%) as unchanged drug.
Half life
The elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed following oral administration. Peak plasma concentrations are achieved in approximately 1-3 hours.
Metabolism
Minimally metabolized; approximately 5% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
Can increase fexofenadine plasma concentrations, but this increase is generally not considered clinically significant.
Antacids containing aluminum and magnesium
May reduce the absorption of fexofenadine. It is recommended to separate administration by approximately 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Fexofenadine is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
Can increase fexofenadine plasma concentrations, but this increase is generally not considered clinically significant.
Antacids containing aluminum and magnesium
May reduce the absorption of fexofenadine. It is recommended to separate administration by approximately 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Fexofenadine is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the specific packaging for exact expiry date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Generic available
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients taking fexofenadine.
Doctor Notes
- Emphasize to patients that fexofenadine is a non-sedating antihistamine.
- Counsel patients on avoiding fruit juices when taking fexofenadine to ensure optimal absorption.
- Advise patients on symptomatic relief and not to expect a cure for underlying allergies.
Patient Guidelines
- Do not take this medicine with fruit juices.
- Do not exceed the recommended dose.
- If symptoms do not improve or worsen, consult your doctor.
- Inform your doctor about all other medicines you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-sedating. However, individuals should be aware of their response to the medication before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hygiene to reduce exposure to allergens.
- Avoid smoking and exposure to secondhand smoke, as it can worsen allergic symptoms.
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