Axodin
Generic Name
Fexofenadine Hydrochloride
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| axodin 180 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Axodin 180 mg Tablet contains Fexofenadine Hydrochloride, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis and chronic idiopathic urticaria: 180 mg once daily.
Elderly
No specific dosage adjustment is generally required, but monitor renal function.
Renal_impairment
For adults with impaired renal function, the recommended starting dose is 60 mg once daily.
How to Take
Take Axodin 180 mg Tablet orally with water, preferably before a meal. Do not take with fruit juices (e.g., grapefruit, orange, apple) as they can reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms, without causing significant drowsiness.
Pharmacokinetics
Onset
Onset of action typically occurs within 1 hour.
Excretion
Primarily excreted unchanged in feces (80%) and urine (10%).
Half life
Elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 1-3 hours.
Metabolism
Undergoes minimal hepatic metabolism (about 5%).
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin
May increase fexofenadine plasma concentrations.
Ketoconazole
May increase fexofenadine plasma concentrations.
Aluminum and Magnesium-containing Antacids
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, and dry mouth. Treatment is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if fexofenadine is excreted in human milk; use with caution in nursing mothers. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin
May increase fexofenadine plasma concentrations.
Ketoconazole
May increase fexofenadine plasma concentrations.
Aluminum and Magnesium-containing Antacids
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, and dry mouth. Treatment is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if fexofenadine is excreted in human milk; use with caution in nursing mothers. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of fexofenadine for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No routine lab monitoring is generally required for patients taking fexofenadine.
Doctor Notes
- Emphasize the importance of avoiding fruit juices (grapefruit, orange, apple) due to reduced bioavailability.
- Advise patients to separate administration of aluminum- and magnesium-containing antacids by at least 2 hours to prevent reduced absorption.
- Reassure patients that fexofenadine is generally non-sedating, but individual variations in response should be considered for tasks requiring alertness.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid consuming fruit juices (grapefruit, orange, apple) while taking this medicine.
- Inform your doctor or pharmacist about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Axodin is generally non-sedating, but individual responses may vary. It is advisable to ascertain individual response before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain a clean living environment to minimize exposure to dust mites and pet dander.
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