Medicine Information

Cefaclav

Name: Cefaclav
Brand: Cefaclav

Oral Suspension125 mg/5 mlAntibiotics (Cephalosporins)ATC: J01DC04

Generic Name

Cefaclor

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefaclav 125 mg suspension	৳ 265.00	N/A

Description

Overview of the medicine

Cefaclav 125 mg Suspension is an antibiotic medication containing Cefaclor, used to treat a variety of bacterial infections.

Uses & Indications

Upper and lower respiratory tract infections (e.g., pharyngitis, tonsillitis, bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections

Otitis media (middle ear infection)

Sinusitis

Dosage

Adults

Typical adult dose is 250-500 mg every 8 hours. Maximum daily dose is 4 g.

Elderly

No specific dose adjustment required unless renal impairment is present.

Renal_impairment

Dosage adjustment needed for severe renal impairment (creatinine clearance < 30 ml/min).

How to Take

Shake well before use. Can be taken with or without food. Complete the full course of treatment as prescribed by the doctor.

Mechanism of Action

Cefaclor is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Rapid; usually within 1-2 hours for therapeutic effect.

Excretion

Primarily excreted by the kidneys via glomerular filtration and tubular secretion.

Half life

Approximately 0.5 to 1 hour.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 0.5 to 1 hour.

Metabolism

Not extensively metabolized; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Cefaclor, other cephalosporins, or any component of the formulation.
History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillin).

Drug Interactions

Metformin

May increase Metformin levels.

Probenecid

Decreases renal excretion of Cefaclor, leading to increased and prolonged plasma concentrations.

Anticoagulants (e.g., Warfarin)

May increase the anticoagulant effect. Monitor INR/PT.

Storage

Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.

Overdose

Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management includes gastric lavage or emesis, and supportive therapy.

Pregnancy & Lactation

Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.

Side Effects

Contraindications

Hypersensitivity to Cefaclor, other cephalosporins, or any component of the formulation.
History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillin).

Drug Interactions

Metformin

May increase Metformin levels.

Probenecid

Decreases renal excretion of Cefaclor, leading to increased and prolonged plasma concentrations.

Anticoagulants (e.g., Warfarin)

May increase the anticoagulant effect. Monitor INR/PT.

Storage

Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.

Overdose

Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management includes gastric lavage or emesis, and supportive therapy.

Pregnancy & Lactation

Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle60 ml bottle

Shelf Life

24 months (unreconstituted powder); 14 days (reconstituted, refrigerated).

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic

Clinical Trials

Extensive clinical trials have established Cefaclor's efficacy and safety for various bacterial infections.

Lab Monitoring

Monitor renal function in patients with pre-existing renal impairment.
Periodic complete blood count (CBC) during prolonged therapy.

Doctor Notes

Counsel patients on the importance of completing the full antibiotic course.
Be aware of potential cross-reactivity with penicillins in allergic patients.

Patient Guidelines

Complete the entire course of medication, even if symptoms improve.
Do not share this medication with others.
Store the suspension in the refrigerator after reconstitution and discard any unused portion after 14 days.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.