Cefaclav
Generic Name
Cefaclor
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefaclav 500 mg tablet | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Cefaclor is a second-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours. Max 4 g/day.
Elderly
Dose similar to adults, but adjust for renal impairment.
Renal_impairment
Initial dose as normal, then adjust frequency based on creatinine clearance (e.g., reduce dose or increase interval).
How to Take
Administer orally with or without food. Complete the full course of treatment.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Rapid (within 30-60 minutes).
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 0.6 to 1 hour.
Absorption
Rapid and well absorbed from the gastrointestinal tract after oral administration. Food may delay absorption but does not affect total amount absorbed.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefaclor, other cephalosporins, or penicillins
- Severe renal impairment without dose adjustment
Drug Interactions
probenecid
Increases and prolongs cefaclor serum levels by inhibiting renal tubular secretion.
aminoglycosides
Concurrent use may increase nephrotoxicity, monitor renal function.
oral_anticoagulants
May potentiate the effects of warfarin and other oral anticoagulants, requiring monitoring of INR.
live_typhoid_vaccine
May reduce the therapeutic effect of the vaccine.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Management involves supportive care and symptomatic treatment. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- Hypersensitivity to cefaclor, other cephalosporins, or penicillins
- Severe renal impairment without dose adjustment
Drug Interactions
probenecid
Increases and prolongs cefaclor serum levels by inhibiting renal tubular secretion.
aminoglycosides
Concurrent use may increase nephrotoxicity, monitor renal function.
oral_anticoagulants
May potentiate the effects of warfarin and other oral anticoagulants, requiring monitoring of INR.
live_typhoid_vaccine
May reduce the therapeutic effect of the vaccine.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Management involves supportive care and symptomatic treatment. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities
Patent Status
Generic available, patent expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of cefaclor in various bacterial infections.
Lab Monitoring
- Renal function (creatinine, BUN) for prolonged therapy or in patients with renal impairment.
- Complete Blood Count (CBC) periodically.
Doctor Notes
- Consider culture and sensitivity testing prior to initiating therapy, especially for severe infections.
- Monitor for signs of allergic reactions, including anaphylaxis, especially in patients with a history of penicillin allergy.
Patient Guidelines
- Take the medication for the full prescribed duration, even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent diarrhea to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally no impairment to drive or operate machinery. However, if dizziness occurs, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration while on antibiotic therapy.
- Avoid alcohol as it may exacerbate gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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