Cefaclav
Generic Name
Cefaclor + Clavulanic Acid
Manufacturer
Reputable Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefaclav 125 mg tablet | ৳ 20.00 | ৳ 140.00 |
Description
Overview of the medicine
Cefaclav 125 mg Tablet is an antibiotic belonging to the cephalosporin group, combined with a beta-lactamase inhibitor. It is used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Typically, higher strengths (e.g., 250 mg or 500 mg Cefaclor equivalent) are preferred for adults, usually 250-500 mg Cefaclor every 8 hours. This 125 mg tablet is generally for pediatric use.
Elderly
Similar to adult dosage; monitor renal function. Dosage adjustments may be needed based on creatinine clearance.
Renal_impairment
For CrCl 10-50 mL/min, administer usual dose less frequently. For CrCl < 10 mL/min, administer usual dose every 12-24 hours.
How to Take
Oral. Can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis. Clavulanic acid is a beta-lactamase inhibitor that prevents bacterial enzymes from inactivating Cefaclor, thereby extending its spectrum of activity against beta-lactamase producing bacteria.
Pharmacokinetics
Onset
Rapid (within 1-2 hours of administration)
Excretion
Primarily excreted unchanged by the kidneys (Cefaclor). Clavulanic acid is excreted renally and non-renally.
Half life
Approximately 0.5 to 1 hour for Cefaclor, Clavulanic acid is also short.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 0.5 to 1 hour.
Metabolism
Cefaclor is minimally metabolized. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Hypersensitivity to cefaclor, clavulanic acid, any other cephalosporin, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Warfarin
May increase anticoagulant effect. Monitor INR.
Probenecid
Increases and prolongs plasma concentrations of cefaclor.
Aminoglycosides
Possible increased nephrotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management includes general supportive measures; gastric lavage or activated charcoal may be considered. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefaclor is excreted in breast milk; use with caution during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to cefaclor, clavulanic acid, any other cephalosporin, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Warfarin
May increase anticoagulant effect. Monitor INR.
Probenecid
Increases and prolongs plasma concentrations of cefaclor.
Aminoglycosides
Possible increased nephrotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management includes general supportive measures; gastric lavage or activated charcoal may be considered. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefaclor is excreted in breast milk; use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Cefaclor and clavulanic acid in treating various bacterial infections.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Complete blood count (prolonged therapy)
Doctor Notes
- Emphasize importance of completing the full course.
- Advise patients on potential for GI upset and to take with food if necessary.
- Be aware of potential cross-reactivity in penicillin-allergic patients (though lower with second-gen cephalosporins).
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
- Avoid alcohol consumption during treatment if you experience side effects like dizziness.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Practice good hygiene to prevent spread of infection.
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Global Brand Names
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