Cefim-3
Generic Name
Cefixime Trihydrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefim 3 200 mg tablet | ৳ 34.00 | ৳ 238.00 |
Description
Overview of the medicine
Cefim-3 200 mg Tablet contains Cefixime Trihydrate, an oral third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections effectively targeting various Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 200 mg every 12 hours or 400 mg once daily, as directed by a physician. Treatment duration typically ranges from 7-14 days depending on the type and severity of infection.
Elderly
No specific dosage adjustment is generally required for elderly patients with normal renal function. However, renal function should be assessed before initiating therapy.
Renal_impairment
For patients with creatinine clearance between 21-60 mL/min, the dose should be reduced to 300 mg daily. For creatinine clearance less than 20 mL/min, the dose should be reduced to 200 mg daily. Patients on chronic ambulatory peritoneal dialysis (CAPD) or hemodialysis should also receive 200 mg daily.
How to Take
Cefim-3 200 mg Tablet should be taken orally, with or without food, as prescribed by your doctor. It is crucial to complete the entire course of treatment, even if your symptoms improve, to ensure complete eradication of the infection and prevent antibiotic resistance.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and subsequent bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are typically achieved within 2-6 hours after oral administration.
Excretion
The main route of excretion is renal, with approximately 50% of an absorbed dose being excreted unchanged in the urine over 24 hours. Some non-renal elimination also occurs.
Half life
The plasma elimination half-life averages 3-4 hours, though it can be longer in patients with renal impairment.
Absorption
Approximately 40-50% of an oral dose is absorbed. Food may delay the time to peak concentration (Tmax) but does not significantly affect the extent of absorption (AUC).
Metabolism
Cefixime undergoes very limited hepatic metabolism; it is primarily excreted as the unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
Concomitant administration may increase the bioavailability of cefixime, potentially leading to higher plasma concentrations.
Carbamazepine
Elevated carbamazepine levels have been reported when administered concomitantly with cefixime. Therapeutic drug monitoring and dosage adjustment of carbamazepine may be appropriate.
Warfarin and other anticoagulants
Concurrent use may increase prothrombin time (PT) and INR, with or without clinical bleeding. Close monitoring of coagulation parameters is advised, and anticoagulant dose adjustment may be necessary.
Storage
Store in a cool, dry place, ideally below 30°C. Protect from light and moisture. Keep all medicines out of the reach and sight of children.
Overdose
In case of a significant overdose, gastric lavage may be indicated to remove unabsorbed drug. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive, addressing any specific symptoms.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution during lactation, and monitor the infant for gastrointestinal disturbances or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
Concomitant administration may increase the bioavailability of cefixime, potentially leading to higher plasma concentrations.
Carbamazepine
Elevated carbamazepine levels have been reported when administered concomitantly with cefixime. Therapeutic drug monitoring and dosage adjustment of carbamazepine may be appropriate.
Warfarin and other anticoagulants
Concurrent use may increase prothrombin time (PT) and INR, with or without clinical bleeding. Close monitoring of coagulation parameters is advised, and anticoagulant dose adjustment may be necessary.
Storage
Store in a cool, dry place, ideally below 30°C. Protect from light and moisture. Keep all medicines out of the reach and sight of children.
Overdose
In case of a significant overdose, gastric lavage may be indicated to remove unabsorbed drug. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive, addressing any specific symptoms.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution during lactation, and monitor the infant for gastrointestinal disturbances or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date, provided proper storage conditions are maintained.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities worldwide, including DGDA Bangladesh, for the treatment of various bacterial infections.
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in numerous clinical trials globally, demonstrating its efficacy and safety for approved indications. Ongoing post-marketing surveillance and phase IV studies continue to gather real-world data on its performance.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN, creatinine clearance) for prolonged therapy or in patients with pre-existing renal impairment.
- Complete Blood Count (CBC) including differential, if therapy is prolonged beyond 10-14 days.
- Liver function tests (e.g., AST, ALT, alkaline phosphatase) rarely, if liver dysfunction is suspected.
Doctor Notes
- Before initiating therapy, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other beta-lactams.
- Assess renal function, particularly in elderly patients or those with known renal impairment, and adjust dosage accordingly.
- Advise patients to complete the entire prescribed course of treatment to minimize the risk of bacterial resistance and relapse.
- Monitor for signs and symptoms of Clostridioides difficile-associated diarrhea (CDAD) if severe diarrhea develops during or after treatment.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor. Do not alter the dose or stop treatment prematurely, even if you feel better.
- Complete the full course of antibiotics to prevent the return of infection and the development of antibiotic resistance.
- Inform your doctor immediately if you experience severe diarrhea (especially watery or bloody stools), persistent nausea, or any signs of an allergic reaction (e.g., rash, itching, swelling, difficulty breathing).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to compensate for a forgotten one.
Driving Precautions
Cefixime may cause dizziness or lightheadedness in some patients. If you experience these symptoms, it is advisable to avoid driving or operating machinery until you are certain how the medicine affects your ability to perform such tasks safely.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids, especially if experiencing diarrhea.
- Avoid alcohol consumption during treatment as it may exacerbate gastrointestinal side effects.
- Follow up with your doctor as advised to monitor your condition and treatment effectiveness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Cefim-3 Brand
Other medicines available under the same brand name
