Adults

This strength (125 mg/5 ml suspension) is primarily for pediatric use. Adult dosage of Cefixime is typically 400 mg once daily or 200 mg twice daily, usually with higher strength tablets/capsules.

Elderly

Dose adjustment may be necessary based on renal function; monitor creatinine clearance. No specific dosage adjustment for age alone.

Renal_impairment

For creatinine clearance 21-60 mL/min, total daily dose should be reduced by 25%. For creatinine clearance <20 mL/min, total daily dose should be reduced by 50%.

Onset

Peak plasma concentrations are generally achieved 2 to 6 hours after oral administration.

Excretion

Primarily excreted unchanged in the urine (approximately 50% of the absorbed dose) and also via biliary excretion.

Half life

Typically 3 to 4 hours in healthy adults, but may be prolonged in elderly patients and those with renal impairment.

Absorption

Approximately 40-50% orally absorbed. Food may slightly delay absorption but does not significantly affect the total absorbed amount.

Metabolism

Cefixime is not extensively metabolized in the body. Only a small portion may be metabolized in the liver.

Probenecid

May increase cefixime plasma concentrations and prolong its elimination half-life by inhibiting renal excretion of cefixime.

Carbamazepine

Concomitant administration has been reported to result in increased carbamazepine plasma concentrations, requiring monitoring of carbamazepine levels.

Oral Contraceptives

Potential for reduced efficacy of oral contraceptives; advise using alternative or additional birth control methods.

Warfarin and other anticoagulants

May increase prothrombin time (PT) and INR, enhancing the anticoagulant effect and increasing the risk of bleeding. Close monitoring of coagulation parameters is recommended.