Adults

Typical dosage is 250 mg to 500 mg twice daily, depending on the severity and type of infection. For uncomplicated urinary tract infections, 250 mg twice daily. For most other infections, 500 mg twice daily.

Elderly

No specific dose adjustment is required solely based on age; however, renal function should be assessed and dosage adjusted if renal impairment is present.

Renal_impairment

Dose reduction is necessary for severe renal impairment (e.g., creatinine clearance < 30 mL/min). For example, 250 mg once daily or 250 mg every 24 hours for severe impairment.

Onset

Therapeutic effects are typically observed within hours to a few days, depending on the infection.

Excretion

Primarily excreted unchanged by glomerular filtration and tubular secretion in the urine.

Half life

Approximately 1.2 to 1.5 hours in adults with normal renal function.

Absorption

Well absorbed after oral administration, especially when taken with food. Hydrolyzed to cefuroxime in the intestinal mucosa and blood.

Metabolism

Cefuroxime itself is not extensively metabolized in the liver.

Probenecid

Concomitant use with probenecid increases cefuroxime concentrations and prolongs its duration of action.

Oral Contraceptives

Cefuroxime may reduce the efficacy of oral contraceptives. Advise patients to use additional barrier contraception.

Warfarin and other oral anticoagulants

Concurrent use may increase the anticoagulant effect of warfarin. Monitor INR closely.

Antacids/H2-receptor antagonists/Proton pump inhibitors

May reduce the bioavailability of cefuroxime axetil by increasing gastric pH.