Adults

The usual adult dose is 200 mg once daily or 100 mg twice daily. For more severe infections or uncomplicated gonorrhea, a single 400 mg dose may be given once daily.

Elderly

No specific dose adjustment is needed for elderly patients unless there is significant renal impairment.

Renal_impairment

Dosage should be adjusted based on creatinine clearance (CrCl). For CrCl 21-60 mL/min, 200 mg daily. For CrCl < 20 mL/min, 100 mg daily.

Onset

Peak plasma concentrations are achieved in 2-6 hours.

Excretion

Primarily excreted by the kidneys, with about 50% of an absorbed dose excreted unchanged in the urine within 24 hours. Non-renal excretion accounts for the remainder.

Half life

Plasma half-life is typically 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent of absorption.

Metabolism

Not extensively metabolized in the body. Some metabolites may be formed but are generally inactive.

Carbamazepine

Concomitant use with cefixime has been reported to increase carbamazepine levels. Therapeutic drug monitoring may be necessary.

Warfarin and other oral anticoagulants

Cefixime may increase the prothrombin time (PT) and INR, potentially leading to an increased risk of bleeding. Close monitoring is recommended.