Cephoral
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cephoral 25 mg pediatric drop | ৳ 100.00 | N/A |
Description
Overview of the medicine
Cefixime is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections in children, including respiratory tract, urinary tract, and ear infections.
Uses & Indications
Dosage
Adults
Not applicable for this pediatric formulation.
Elderly
Not applicable for this pediatric formulation.
Renal_impairment
For children with creatinine clearance (CrCl) <30 mL/min, dosage reduction is required. Consult a physician for specific adjustments.
How to Take
Administer orally, with or without food. Shake the bottle well before each use. Can be mixed with a small amount of water, milk, or formula immediately before administration.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the interruption of peptidoglycan synthesis, which ultimately causes cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved within 2-6 hours after oral administration.
Excretion
Approximately 50-60% of the absorbed dose is excreted unchanged in the urine over 24 hours. Biliary excretion is also a route of elimination.
Half life
The plasma elimination half-life is typically 3-4 hours, but can extend to 6-8 hours.
Absorption
Approximately 40-50% of an oral dose is absorbed. Absorption may be slightly delayed by food but the total amount absorbed is not significantly affected.
Metabolism
Cefixime is not extensively metabolized in the body. There are no active metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- •History of severe hypersensitivity reaction (e.g., anaphylaxis) to any penicillin antibiotic.
Drug Interactions
Probenecid
Increases cefixime plasma concentrations and prolongs its elimination half-life by decreasing renal tubular secretion.
Carbamazepine
Concomitant use may increase carbamazepine levels; monitoring is advised.
Warfarin and other anticoagulants
May increase prothrombin time (INR), requiring close monitoring and possible anticoagulant dose adjustment.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period (typically 14 days). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not substantially removed by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have not shown a risk. Use in pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: Typically 24-36 months. Reconstituted suspension: Stable for 7 days at room temperature (20-25°C) or 14 days under refrigeration (2-8°C).
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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