Cephoral
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cephoral 400 mg capsule | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections susceptible to Cefixime.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg every 12 hours. Treatment duration usually 7-14 days depending on infection type.
Elderly
No dosage adjustment is required in elderly patients with normal renal function. Monitor renal function.
Renal_impairment
For creatinine clearance 21-60 mL/min: 300 mg daily. For creatinine clearance <20 mL/min: 200 mg daily. Hemodialysis and CAPD patients: 200 mg daily.
How to Take
Cephoral 400 mg Capsule should be taken orally with or without food. It is absorbed well after oral administration.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours.
Excretion
Approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours. Some biliary excretion occurs.
Half life
Plasma elimination half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, influenced by food but not to a clinically significant extent.
Metabolism
Not extensively metabolized in the liver; limited metabolism has been observed.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
Concurrent administration may prolong prothrombin time (INR).
Nifedipine
Concurrent use may increase Cefixime absorption and peak plasma levels.
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent use.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Supportive care is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
Concurrent administration may prolong prothrombin time (INR).
Nifedipine
Concurrent use may increase Cefixime absorption and peak plasma levels.
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent use.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Supportive care is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime is a well-established antibiotic with numerous clinical trials supporting its efficacy and safety profile for approved indications.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Complete blood count (CBC) for prolonged therapy
- Liver function tests (if clinically indicated)
Doctor Notes
- Consider local susceptibility patterns when prescribing Cefixime.
- Adjust dosage in patients with significant renal impairment.
- Advise patients on the importance of completing the full course to prevent resistance.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Inform your doctor about any history of allergies, especially to antibiotics.
- Report severe or persistent diarrhea to your doctor, as it may be a sign of a more serious condition.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be cautious when driving or operating machinery if they experience such effects.
Lifestyle Advice
- Maintain good hydration during the course of treatment.
- Avoid self-medication for future infections.
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