Cerox-A
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cerox a 250 mg tablet | ৳ 30.00 | ৳ 120.00 |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
250 mg or 500 mg twice daily, depending on the severity and type of infection. For most infections, 250 mg twice daily. For severe infections or lower respiratory tract infections, 500 mg twice daily.
Elderly
No specific dose adjustment is generally needed unless severe renal impairment is present.
Renal_impairment
Dose adjustment required for severe renal impairment (creatinine clearance < 30 mL/min). Consult a physician for specific dosing.
How to Take
Administer orally, preferably with food for optimal absorption and to reduce gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically within 1-2 hours after oral administration.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after oral administration and hydrolyzed to cefuroxime in the intestinal mucosa and blood. Bioavailability is increased when taken with food.
Metabolism
Not extensively metabolized in the body; primarily undergoes hydrolysis.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration-time curve of cefuroxime by about 50%, prolonging its half-life.
Oral Contraceptives
Cefuroxime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Advise additional contraception.
Aminoglycosides and Diuretics
Concurrent use of high doses of cephalosporins with aminoglycosides or potent diuretics (e.g., furosemide) may increase the risk of nephrotoxicity.
Antacids/H2-receptor antagonists
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of cephalosporins can cause cerebral irritation leading to convulsions. Management is primarily symptomatic and supportive. Hemodialysis may be used to aid in the removal of cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration-time curve of cefuroxime by about 50%, prolonging its half-life.
Oral Contraceptives
Cefuroxime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Advise additional contraception.
Aminoglycosides and Diuretics
Concurrent use of high doses of cephalosporins with aminoglycosides or potent diuretics (e.g., furosemide) may increase the risk of nephrotoxicity.
Antacids/H2-receptor antagonists
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of cephalosporins can cause cerebral irritation leading to convulsions. Management is primarily symptomatic and supportive. Hemodialysis may be used to aid in the removal of cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
DGDA approved
Patent Status
Generic available, Off-patent
WHO Essential Medicine
YesClinical Trials
Cefuroxime Axetil has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Periodic assessment of renal function is advised, especially in patients receiving prolonged therapy or who have pre-existing renal impairment. Liver function tests may be monitored occasionally.
Doctor Notes
- Emphasize the importance of completing the full course of antibiotics to patients to prevent treatment failure and resistance.
- Consider dose adjustment in patients with severe renal impairment.
- Counsel patients regarding potential gastrointestinal side effects and the benefit of taking with food.
Patient Guidelines
- Complete the full prescribed course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Take the tablet with food to enhance absorption and minimize stomach upset.
- Report any severe or persistent side effects to your doctor.
- Do not share your medication with others.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefuroxime Axetil may cause dizziness. Patients should be warned to be cautious when driving or operating machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Ensure adequate fluid intake unless otherwise advised by a physician.
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