Cerox-A
Generic Name
Cefuroxime Axetil 500 mg Tablet
Manufacturer
Aristopharma Limited
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
cerox a 500 mg tablet | ৳ 50.00 | ৳ 200.00 |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum, second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typical dose: 250 mg to 500 mg twice daily depending on the infection. For severe infections or pneumonia, 500 mg twice daily. For uncomplicated UTIs: 250 mg twice daily.
Elderly
Similar to adult dosage, but dose adjustment may be required in elderly patients with reduced renal function.
Renal_impairment
Dosage should be reduced in patients with significant renal impairment. CrCl 10-29 mL/min: 250-500 mg every 24 hours. CrCl <10 mL/min: 250-500 mg every 48 hours.
How to Take
Take orally with food for optimum absorption. Do not crush the tablet; swallow whole.
Mechanism of Action
It works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached in approximately 2-3 hours after oral administration with food.
Excretion
Excreted unchanged in the urine, primarily by glomerular filtration and tubular secretion.
Half life
Approximately 1 to 1.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food, converting rapidly to cefuroxime.
Metabolism
Cefuroxime itself is not significantly metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime axetil, any other cephalosporin antibiotic, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration significantly increases cefuroxime plasma concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives. Additional contraceptive measures may be necessary.
Live bacterial vaccines
Antibiotics may reduce the therapeutic effect of live bacterial vaccines (e.g., typhoid vaccine).
Antacids/H2-blockers/PPIs
Concomitant administration may reduce the bioavailability of cefuroxime axetil by altering gastric pH. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdosage with cefuroxime may lead to neurological sequelae including encephalopathy, convulsions, and coma. Management is supportive; hemodialysis or peritoneal dialysis may be considered to reduce serum concentrations.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime axetil, any other cephalosporin antibiotic, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration significantly increases cefuroxime plasma concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives. Additional contraceptive measures may be necessary.
Live bacterial vaccines
Antibiotics may reduce the therapeutic effect of live bacterial vaccines (e.g., typhoid vaccine).
Antacids/H2-blockers/PPIs
Concomitant administration may reduce the bioavailability of cefuroxime axetil by altering gastric pH. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdosage with cefuroxime may lead to neurological sequelae including encephalopathy, convulsions, and coma. Management is supportive; hemodialysis or peritoneal dialysis may be considered to reduce serum concentrations.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to manufacturer.
Availability
Available in pharmacies
Approval Status
Approved (Globally)
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trial data supports the efficacy and safety of cefuroxime axetil for various bacterial infections.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Liver function tests (periodically during prolonged therapy)
- Complete blood count (for prolonged therapy or if blood dyscrasias are suspected)
Doctor Notes
- Before prescribing, inquire about patient's hypersensitivity history to cephalosporins or penicillins.
- Advise patients to complete the full course of therapy to ensure eradication of infection and prevent resistance.
- Consider renal function in elderly and renally impaired patients for dose adjustment.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve, to prevent resistance and recurrence.
- Take with food to enhance absorption and reduce gastrointestinal upset.
- Do not crush or chew the tablet; swallow it whole.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness; caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption during the course of treatment as it may exacerbate side effects.
- Practice good hygiene to prevent spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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