Cerox-A
Generic Name
Cefuroxime Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cerox a 750 mg injection | ৳ 175.00 | N/A |
Description
Overview of the medicine
Cerox-A 750 mg Injection contains Cefuroxime, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Usually 750 mg three times daily (every 8 hours) by IM or IV injection. For severe infections, the dose may be increased to 1.5 g three times daily. For surgical prophylaxis, 1.5 g IV 30-60 minutes before surgery, followed by 750 mg IM/IV every 8 hours for up to 24-48 hours.
Elderly
No specific dose reduction required in elderly patients with normal renal function. Dose should be adjusted based on renal function if impaired.
Renal_impairment
Dosage adjustment is necessary. For creatinine clearance 10-20 mL/min, 750 mg twice daily. For creatinine clearance <10 mL/min, 750 mg once daily. For hemodialysis patients, 750 mg after each dialysis session.
How to Take
For intramuscular administration, dissolve the powder in sterile water for injection. For intravenous administration, reconstitute the powder and then dilute with a suitable intravenous fluid and administer over 3 to 5 minutes or infuse over 30 to 60 minutes.
Mechanism of Action
Cefuroxime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid, typically within minutes for IV administration.
Excretion
Mainly excreted unchanged by glomerular filtration and tubular secretion via the kidneys.
Half life
Approximately 1-1.5 hours in adults with normal renal function.
Absorption
Rapidly absorbed after intramuscular (IM) administration, reaching peak plasma concentrations within 30-60 minutes. Intravenous (IV) administration results in immediate peak concentrations.
Metabolism
Not significantly metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporins, or to any of the excipients.
- History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases cefuroxime serum concentrations and prolongs its half-life.
Oral Anticoagulants
Concomitant use may increase the anticoagulant effect.
Nephrotoxic drugs (e.g., aminoglycosides, loop diuretics)
Concurrent administration with potentially nephrotoxic drugs may increase the risk of renal toxicity.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored for a short period as directed.
Overdose
Overdose can lead to neurological sequelae including convulsions. Management is symptomatic and supportive. Hemodialysis and peritoneal dialysis can reduce serum levels.
Pregnancy & Lactation
Cefuroxime crosses the placenta and is excreted in breast milk in small amounts. Use during pregnancy and lactation only if clearly needed and benefits outweigh risks.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporins, or to any of the excipients.
- History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases cefuroxime serum concentrations and prolongs its half-life.
Oral Anticoagulants
Concomitant use may increase the anticoagulant effect.
Nephrotoxic drugs (e.g., aminoglycosides, loop diuretics)
Concurrent administration with potentially nephrotoxic drugs may increase the risk of renal toxicity.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored for a short period as directed.
Overdose
Overdose can lead to neurological sequelae including convulsions. Management is symptomatic and supportive. Hemodialysis and peritoneal dialysis can reduce serum levels.
Pregnancy & Lactation
Cefuroxime crosses the placenta and is excreted in breast milk in small amounts. Use during pregnancy and lactation only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date when stored correctly.
Availability
Hospitals, Pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Cefuroxime for various bacterial infections since its introduction.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with impaired renal function or on high doses.
- Liver function tests occasionally.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Confirm susceptibility of the causative organism before initiating therapy.
- Careful monitoring of renal function is essential, especially in elderly patients or those with pre-existing renal impairment.
- Advise patients about the importance of completing the full course to prevent resistance.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any allergic reactions, such as rash or difficulty breathing, immediately.
- Inform your doctor about all other medications you are taking.
- Do not share this medication with others.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it is almost time for the next dose. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Practice good hygiene to prevent further infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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