Cerox-CV
Generic Name
Cefuroxime Axetil + Clavulanic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cerox cv 500 mg tablet | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Cerox-CV 500 mg Tablet is a combination antibiotic containing Cefuroxime Axetil and Clavulanic Acid. It is used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media. Cefuroxime is a cephalosporin antibiotic that kills bacteria by inhibiting cell wall synthesis, while Clavulanic Acid prevents the inactivation of cefuroxime by beta-lactamase enzymes produced by some bacteria, thereby extending its spectrum of activity.
Uses & Indications
Dosage
Adults
One tablet (Cefuroxime 500 mg + Clavulanic acid 125 mg) twice daily for 7-10 days, or as directed by the physician.
Elderly
No specific dose adjustment is usually required unless there is significant renal impairment.
Renal_impairment
Dose adjustment may be necessary based on creatinine clearance. For CrCl 10-30 mL/min, one tablet once daily. For CrCl <10 mL/min, one tablet every 48 hours.
How to Take
Should be taken orally with food to enhance absorption and reduce gastrointestinal discomfort.
Mechanism of Action
Cefuroxime is a second-generation cephalosporin that binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamase enzymes, protecting cefuroxime from degradation and allowing it to exert its bactericidal effect against beta-lactamase-producing strains.
Pharmacokinetics
Onset
Typically within 1-2 hours
Excretion
Mainly excreted unchanged by the kidneys via glomerular filtration and tubular secretion. Clavulanic acid is also primarily excreted by the kidneys.
Half life
Approximately 1-1.5 hours for cefuroxime; 1 hour for clavulanic acid.
Absorption
Well absorbed from the gastrointestinal tract after oral administration, especially with food. Cefuroxime axetil is rapidly hydrolyzed to cefuroxime in the intestinal mucosa and blood.
Metabolism
Cefuroxime is not significantly metabolized; clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, clavulanic acid, any other cephalosporin, or penicillin
- History of cholestatic jaundice/hepatic dysfunction associated with penicillin or cephalosporin use
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. INR monitoring is recommended.
Probenecid
Increases cefuroxime plasma levels and prolongs its half-life by reducing renal tubular secretion.
Oral Contraceptives
May reduce the efficacy of oral contraceptives. Advise additional contraceptive methods.
Antacids/H2 blockers
May reduce the bioavailability of cefuroxime axetil if taken concurrently; administer at least 1-2 hours apart.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances, seizures, and neurological disorders. Treatment is supportive; hemodialysis can aid in removal from the system.
Pregnancy & Lactation
Category B for pregnancy (FDA). Use only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, clavulanic acid, any other cephalosporin, or penicillin
- History of cholestatic jaundice/hepatic dysfunction associated with penicillin or cephalosporin use
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. INR monitoring is recommended.
Probenecid
Increases cefuroxime plasma levels and prolongs its half-life by reducing renal tubular secretion.
Oral Contraceptives
May reduce the efficacy of oral contraceptives. Advise additional contraceptive methods.
Antacids/H2 blockers
May reduce the bioavailability of cefuroxime axetil if taken concurrently; administer at least 1-2 hours apart.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances, seizures, and neurological disorders. Treatment is supportive; hemodialysis can aid in removal from the system.
Pregnancy & Lactation
Category B for pregnancy (FDA). Use only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory bodies like DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefuroxime axetil in various bacterial infections, with clavulanic acid enhancing its spectrum against beta-lactamase producing strains.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment
- Liver function tests if hepatic dysfunction is suspected
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Emphasize completing the full course to minimize resistance development.
- Consider renal function in elderly patients or those with pre-existing kidney disease for dose adjustment.
- Counsel patients on potential gastrointestinal side effects and the importance of taking with food.
Patient Guidelines
- Complete the full course of antibiotics even if symptoms improve to prevent resistance.
- Take with food to aid absorption and reduce stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
- Maintain good hygiene to prevent further infections.
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Global Brand Names
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